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Molecular Medicine Peer-reviewed scientific journal

Molecular Medicine

INTRODUCTION OF MODIFIED mRNA hTERT, CAUSES SHORT-TERMTELOMERASE ACTIVITY IN HUMAN SKIN FIBROBLASTS

Dashinimaev E.B., Faizullin R.R., Zhang Meng, Muchkaeva I.A., Terskikh V.V., Sukhanov Y.V., Vasiliev A.V.

Authors and affiliations

E.B. Dashinimaev, R.R. Faizullin, Zhang Meng, I.A. Muchkaeva, V.V. Terskikh, Y.V. Sukhanov, A.V. Vasiliev
Koltzov Institute of Developmental Biology, Russian Academy of Sciences.

Published
2012

Abstract

Reprogramming of human cells without genetic modification is increasingly used technology in experimental cell biology. One of these
promising methods is the transfection of synthesized mRNA of transcription factors. In this study we synthesized a modified mRNA of the
human telomerase reverse transcriptase (hTERT) and it was shown that its introduction into human cells induces a short-term telomerase
activity. This strategy can be used in the future to increase proliferative ability of the cell cultures, for different applications.

Keywords

Authors and affiliations

E.B. Dashinimaev, R.R. Faizullin, Zhang Meng, I.A. Muchkaeva, V.V. Terskikh, Y.V. Sukhanov, A.V. Vasiliev
Koltzov Institute of Developmental Biology, Russian Academy of Sciences.

How to cite

Dashinimaev E.B., Faizullin R.R., Zhang Meng, Muchkaeva I.A., Terskikh V.V., Sukhanov Y.V., Vasiliev A.V. (2012). INTRODUCTION OF MODIFIED mRNA hTERT, CAUSES SHORT-TERMTELOMERASE ACTIVITY IN HUMAN SKIN FIBROBLASTS. Molecular Medicine, (6).

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