Abstract
In the current study the association of the endothelial nitric oxide synthase (NOS3) gene G894T and VNTR polymorphisms with the
risk of miscarriage in ethnically homogeneous population has been investigated. The frequency of A/B VNTR genotype was revealed to
predominate among chromosomally normal dead first-trimester embryos in missed miscarriage (37%) if compared with newborns (25%;
P=0,02). In dead embryos the 894TT genotype was registered less frequently (4%) than in nonagenarians (12%; P = 0,03). Thus, genotype
AB VNTR is associated with increased risk (OR =1,77; 95%CI:1,11–2,83; P=0,02), and the genotype 894TT has a protective effect against
of this pathology (OR = 0,29, 95%CI:0,09–0,89; P = 0,03).
Authors and affiliations
M.S. Nazarenko, O.Yu. Botkina, V.P. Puzyrev
Research Institute of Medical Genetics, Siberian Branch, Russian Academy of Medical Sciences