Table of contents
ОБЗОРЫ
PHARMACOGENETICS OF BISPHOSPHONATES IN OSTEOPOROSIS
Bisphosphonates (BP) is – a class of drugs that exhibit high inhibitory activity to osteoclasts. BFs are the most effective drugs recommended for the treatment of osteoporosis (OP), which is one of the common diseases of bone tissue, when the risk of bone frac…
GENETICS OF NONCLASSIC FORM OF CONGENITAL ADRENAL HYPERPLASIA: REVIEW AND STUDY RESULTS
Congenital adrenal hyperplasia (CAH) is a group of disorders caused by mutations in genes that encode steroidogenic enzymes. The most frequent form of CAH is caused by defects in CYP21A2 gene leading to 21-hydroxylase deficiency (21-OHD). There are 3 clinical …
CHILDHOOD OBESITY AS A RESULT OF DETERIORATION OF THE FORMATION OF A CIRCADIAN RHYTHM OF MELATONIN IN EARLY ONTOGENESIS
The review presents literature data that are demonstrating the role of adverse environmental factors at the early stages of ontogenesis in programming and realization of the childhood obesity. In the presence of multiple factors contributing to the obesity, th…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
CELLULAR MICROENVIRONMENT OF UVEAL MELANOMA: CLINICAL AND MORPHOLOGICAL CORRELATIONS AND PREDICTORS OF BAD PROGNOSIS
Introduction. Uveal melanoma is a malignant neoplasm of neuroectodermal origin, prone to early metastasis. The tumor microenvironment, including «inflammatory cells» and connective tissue cells, affects its progression, angiogenesis and metastasis. Purpose. To…
FABOMOTIZOLE AS MEANS OF PHARMACOLOGICAL CORRECTION OF PRE- AND POSTNATAL DISTURBANCES INDUCED BY PEAT SMOKE POLLUTION, TOBACCO SMOKE, ALCOHOL, HYPERGLYCEMIA AND CYCLOPHOPHAMIDE IN THE DEVELOPMENT OF OFFSPRING OF RATS
Introduction. Influence of environmental hazards on pregnant women or development of pregnancy in presence of pathogenic pathway may lead to miscarriage, teratogenic effects and/or significant abnormalities in physical development, cognitive and behavioral sta…
MOLECULAR GENETIC CHARACTERISTICS OF NON-SMALL CELL LUNG CANCER USING MULTI-TARGET SINGLE-BASE ELONGATION AND FRAGMENT ANALYSIS
Background. Lung cancer is the most frequent cause of cancer mortality. The prevailing type is non-small cell lung cancer (NSCLC), in the treatment of which EGFR tyrosine kinase inhibitors are actively used, as well as a combination of BRAF and MEK inhibitors.…
THE PROFILES OF LACTOBACILLLUS MICROFLORA AND LOCAL IMMUNE RESPONSE OF THE VAGINAL MUCOSA IN THE DIAGNOSIS OF VAGINAL INFECTIONS
Introduction. In vaginal infections, both microbial factor and the state of local (mucosal) immunity, determined by the immunological reactivity of the macroorganism, play an important role in the pathogenesis of an infectious process. Aim of the studying. To …