Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
STIMULATING EFFECT OF TETRAPEPTIDE AEDG ON MORPHOLOGIC AND FUNCTIONAL CHARACTERISTICS OF THE NERVOUS TISSUE
Introduction. The investigation of biologic active substances, correcting the morphologic and functional characteristics of tissue changes, is an actual medicine task by the pathology therapy. Purpose of the study was the investigation of tetrapeptide AEDG eff…
ANTIHYPOXIC ACTIVITY OF VARIOUS ETHYLMETHYLHYDROXYPYRIDINE SALTS
Introduction. The pathological state of hypoxia of the body occurs with an inadequate supply of tissues and organs with oxygen or with a violation of its utilization in the process of biological oxidation. Ethylmethylhydroxypyridine has a multi-component mecha…
DEVELOPMENT AND VALIDATION OF HPLC-MS/MS METHOD OF DETERMINATION OF A NEW VALPROIC ACID DERIVATIVE AND 1,3,4-THIADIAZOLE IN RAT BRAIN
Introduction. To assess the pharmacokinetic indices of new drugs, it is necessary to develop analytical methods for determining their concentration in biological objects. Purpose of the study. Development and validation of HPLC-mass spectrometric methods for t…
EVALUATION OF N-GLYCOSYLATION PROFILE OF RECOMBINANT BLOOD COAGULATION FACTOR VIIa MOLECULE
Introduction. The specific activity of blood coagulation factor VIIa depends, among other things, on the presence of N-acetylneuraminic acid (sialic acid) and phosphate residues in the molecule. Thus the authenticity of glycosylation profile as one efficacy an…
HYALURONIC ACID PREPARATIONS REGULATE THE EXPRESSION OF TYPE I COLLAGEN AND MATRIX METALLOPROTEINASE 9 IN HUMAN SKIN
Introduction. The decline in collagen I type synthesis and the gain in matrix metalloproteinases (MMPs) activity are the main characteristics of the molecular skin aging. MMPs are ferments which cleave collagen. The aim of the study was to investigate the infl…
REGULARITIES OF CHANGES IN α1-ANTITRYPSIN LEVEL IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA
Introduction. The main function of alpha-1 antitrypsin (A1AT) is inhibition of neutrophil elastinase and control over TNFα secretion. Anti-inflammatory properties of A1AT are manifested in leucocyte migration decrease and proliferation of T-lymphocytes through…
ПЕРЕДОВАЯ СТАТЬЯ
ACTUALITY AND PERSPECTIVES FOR THE PERSONALIZED APPROACH TO THE ALTERATION IN FUNCTIONAL ACTIVITY OF THE IMMUNE SYSTEM BASED ON MICRONUTRIENTS
The review article discusses the principles of a personalized approach to changing the functional activity of the immune system based on micronutrients. The activity of the immune cells has been demonstrated to depend on the level of supplied not only macro- b…
ОБЗОРЫ
NEURODEGENERATIVE DISEASES AND BIOMEDICAL CELL PRODUCTS: RELEVANCE, DIRECTIONS, AND PROBLEMS OF DEVELOPMENT
Progress in clinical research and medicine has contributed to a significant reduction in the worldwide mortality rate. Currently, the strategy of developed countries is directed at increasing expectancy and improving life quality. As a consequence, the modern …
HYALURONIC ACID: ROLE IN THE CELL CYCLE
The review considers the system of hyaluronic acid (HA), represented by its receptors, the enzymes of synthesis (hyaluronan synthase), cleavage (hyaluronidase). The participation of the HA system in the regulation of the cell cycle was demonstrated. The most i…
β2 MICROGLOBULIN AND THE AGING PROCESS
The problems of longevity increase and its quality improvement are actual for the modern gerontology. So far it is necessary to complete tasks of early diagnostic and target prophylactic of the age-associated pathology. There are presented the data concerning …