Abstract
Objective: to analyze the literature data on HPgV infection caused by the Human pegivirus-1 virus (formerly hepatitis G, HGV, GBV-C). Materials and methods: search, by keywords, publications in Scopus, PubMed and Elibrary databases for the period from 1995 to 2020. Results: the history of the study of the virus, its structure, genetic heterogeneity, as well as the problem of epidemiology, tropism and pathogenesis of this infection are described. Due to the presence of a number of the virus properties, possible prospects of HPgV infection research for population genetics and gene therapy are reflected. The modern data on the relationship of HPgV infection with HIV infection, lymphomas and some other diseases are presented. A brief description of a relatively recently described HPgV-2 is presented. The problems of diagnosis and interpretation of HPgV infection in the Russian Federation and foreign countries are outlined. Conclusion: Although HPgV was originally described as the cause of hepatitis, it is not a cytopathic virus, and infection is not associated with the development of pathological processes.
Authors and affiliations
V.V. Litvinov(1), G.G. Freynd(1), V.P. Korobov(2), A.D. Shestakova(3) 1-FSBEI HE «Academician Ye.A. Vagner Perm State Medical University» of the Ministry of Healthcare of the Russian Federation, st. Petropavlovskaya 26, Perm, 614000, Russian Federation; 2-FSBSI Perm Federal Research Center «Institute of Ecology and Genetic of Microorganisms» Ural Office of the Russian Academy of Sciences, st. Goleva 13, Perm, 614081, Russian Federation; 3-FSBI «National medical research center of Oncology named after N.N. Petrov» Ministry of Healthcare of the Russian Federation, st. Leningradskaya, 68, pos. Sandy, St. Petersburg, 197758, Russian Federation E-mail: drlitvinov@mail.ru
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