Abstract
Introduction: Studying the relationship between functional dyspepsia and gut microbiota will provide insight into the role of individual microorganisms and their metabolic products in the development of this pathology. The aim of the study was to analyze the microbiota of patients diagnosed with functional dyspepsia.
Materials and methods: Using the Ion Torrent PGM platform, sequencing of the V3 region of the 16S rRNA gene was performed.
Results: Differential analysis of the abundance showed that patients with dyspepsia have Corynebacterium jeikeium and Eggerthella lenta bacteria in the intestines, which have previously been associated with a number of inflammatory diseases. A relationship was established between Erysipelotrichaceae UCG-003 bacterium, Fusicatenibacter saccharivorans and Turicibacter sanguinis and dyspepsia.
Conclusion: The fecal microbiota characteristics of patients with dyspepsia were studied. The results showed a relationship between individual species and this pathology. For the first time, the relationship between the species Erysipelotrichaceae UCG-003 bacterium, Fusicatenibacter saccharivorans and Turicibacter sanguinis and functional dyspepsia was demonstrated.
Authors and affiliations
I.Yu. Burakova(1), M.V. Gryaznova(1), Y.D. Smirnova(1), P.D. Morozova(1, 2), P.A. Chizhkov(2), S.N. Lagutina(3), M.Yu. Syromyatnikov(1, 2)
1Laboratory of metagenomics and food biotechnology, Voronezh State University of Engineering Technologies,
Revolution av. 19, Voronezh, 394036, Russian Federation; 2Department of Genetics, Cytology and Bioengineering,
Voronezh State University, Universitetskaya sq. 1, Voronezh, 394018, Russian Federation; 3Department of Polyclinic Therapy,
Voronezh State Medical University Named after N.N. Burdenko, Studencheskaya st. 10, Voronezh, 394036, Russia
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