Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
Interaction in the PAMPs – mucosal barrier – cytokines system in children with obesity
Introduction. The significant increase in obesity among children and adolescents necessitates the search for ways to prevent and treat it. Inflammation in obesity is the main mechanism leading to comorbid changes. Aim of the study. To establish correlations be…
Single nucleotide variant of the epithelial sodium channel gene SCNN1A (RS11064153) as a predictor of the development of arterial hypertension
Relevance. Poor blood pressure control remains a leading cause of cardiovascular morbidity and mortality worldwide. Despite the fact that today information is actively accumulating about various genetic markers as predictors of many diseases, information about…
ASSESSMENT OF C-REACTIVE PROTEIN, PRESEPSIN AND LIPOPOLYSACCHARIDE-BINDING PROTEIN LEVELS IN CARDIAC SURGERY PATIENTS WITH POSTOPERATIVE INFECTIOUS-INFLAMMATORY COMPLICATIONS
Introduction Postoperative infectious and inflammatory complications worsen the prognosis of patients, increase the duration of hospitalization and increase the cost of treatment, therefore, the search for markers to determine the degree of risk of their devel…
Using claudin-2 to mark mossy fibers in the mouse hippocampus
The purpose of the present study was to test the possibility of identifying hippocampal mossy fiber projections by staining mouse brain sections with antibodies to the claudin-2 protein. Material and methods: the subjects of the study were 9 male wild mice. Se…
Serotonin, 5-HIAA, and membrane serotonin transporter in blood as biomarkers of familial hypercholesterolemia in immature low-density lipoprotein receptor-deficient mice
Introduction. Cardiovascular diseases are the main cause of death and disability in the world population. Serotonin plays a significant role in the development and progression of atherosclerotic processes due to its two classical functions – platelet aggregati…
Рroliferotropic effect of peptides in liver organotypic tissue culture of different age rats
Introduction. One of the actual task of modern biology and medicine is the creation of bioregulator preparation, which have the proliferotropic effect on the internal organs of organism. Purpose of study. Study of proliferotropic effect of short peptides and p…
Prognostic significance of CD68+ macrophages in autoimmune inflammation in experimental study
Introduction. Autoimmune oophoritis is one of the causes of premature ovarian insufficiency in 3–40% of cases. Representative diagnosis is possible only through histological examination of ovarian biopsy material, which complicates the identification of early …
ОБЗОРЫ
ORAL FLUID LEPTIN IS NORMAL AND PATHOLOGICAL
Introduction. Leptin is a representative of biologically active compounds produced by adipose tissue – adipokines. The traditional material for his research is blood. Saliva is a local secret of the glands of the initial part of the digestive tract, which has …
Neurotoxic complications of cancer chemotherapy
Introduction. Neurotoxicity is a common complication of chemotherapy that negatively affects the quality of life of cancer patients. Damage to the nervous system affects both the peripheral nerves (peripheral neuropathy) and the central nervous system (chemo b…
The Role of P2X7 Receptors in the Pathogenesis of Depression and Autism Spectrum Disorders
Introduction. Purinergic signaling pathways in brain cells can play an important role both in physiological conditions and in depression and autism spectrum disorders. The purpose of this literature review was a systematic analysis of information in the modern…