Abstract
coronary artery disease, epithelial-mesenchymal transition, cadherins, connexins, transforming growth factor-β, pannexins
Keywords
Authors and affiliations
https://elibrary.ru/qswqfy
M.V. Mnikhovich(1, 2), N.V. Yenenkov(3), I.A. Shiripenko(1, 2), T.V. Bezuglova(1), M.V. Lozina(1, 2), M.V. Dronova(4), P.O. Gromov(2), D.D. Kaminer(5)
1-Avtsyn Research Institute of Human Morphology of Federal state budgetary scientific institution “Petrovsky National Research Centre of Surgery”, Tsyurupy str. 1, Moscow, 117418, Russian Federation; 2Petrovsky Medical University of Federal State Budgetary Scientific
Institution “Petrovsky National Research Centre of Surgery”, Abrikosovsky str. 2, Moscow, 119435, Russian Federation; 3Ryazan State
Medical University, Vysokovoltnaya, 9, Ryazan, 390026, Russian Federation; 4Bunin Yelets State University, Kommunarov str., 28, Yelets, 399770, Russian Federation; 5Federal State Autonomous Educational Institution of Higher Education “N.I. Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian Federation, Ostrovityanova str. 1, Moscow, 119049, Russian Federation
References
Барбараш О.Л., Карпов Ю.А., Панов А.В. и др. Стабильная ишемическая болезнь сердца. Клинические рекомендации 2024. Российский кардиологический журнал. 2024; 29 (9): 6110. DOI: 10.15829/1560-4071-2024-6110. [Barbarash O.L., Karpov Yu.A., Panov A.V. et al. Stable ischemic heart disease. Clinical guidelines 2024. Russian J. of cardiology. 2024; 29 (9): 6110. (In Russ.)]
Koelwyn G.J., Corr E.M., Erbay E., Moore K.J. Regulation of macrophage immunometabolism in atherosclerosis. Nat Immunol. 2018; 19 (6): 526–37. DOI: 10.1038/s41590-018-0113-3
Poznyak A.V., Grechko A.V., Orekhova V.A., Chegodaev Y.S., Wu W.K., Orekhov A.N. Oxidative Stress and Antioxidants in Atherosclerosis Development and Treatment. Biology (Basel). 2020; 9 (3): 60. DOI: 10.3390/biology9030060
Yang J., Antin P., Berx G., Blanpain C. et al. Guidelines and definitions for research on epithelial-mesenchymal transition. Nat Rev Mol. Cell. Biol. 2020; 21 (6): 341–52. DOI: 10.1038/s41580-020-0237-9.
Стрельникова Е.А., Калинин Р.Е., Сучков И.А., Короткова Н.В., Мжаванадзе Н.Д. Молекулярно-клеточные аспекты эндотелиально-мезенхимального перехода при сердечно-сосудистых заболеваниях Молекулярная биология. 2023; 57 (4): 563–72. DOI: 10.31857/S0026898423030138. [Strelnikova E.A., Kalinin R.E., Suchkov I.A., Korotkova N.V., Mzhavanadze N.D. Molecular and cellular aspects of endothelial-mesenchymal transition in cardiovascular diseases Molecular biology. 2023; 57 (4): 563–72. (In Russ.)]
. Spillmann F., Miteva K., Pieske B. et al. High-density lipoproteins reduce endothelial-to-mesenchymal transition. Arterioscler Thromb Vasc Biol. 2015; 35: 1774–7. DOI: 10.1161/ATVBAHA.115.305887.
. Tombor L.S., John D., Glaser S.F. Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction. Nat. Commun. 2021; 12: 681.
. Acebron S.P., Niehrs C. β-catenin independent roles of Wnt/LRP6 signaling. Trends Cell Biol. 2016; 26: 956–67.
. Wu Y., Zhou L., Liu H. et al. LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration. Cell Res. 2021; 31 (4): 450–62. DOI: 10.1038/s41422-020-00411-7
. Xiong J., Kawagishi H., Yan Y. et al. A Metabolic Basis for Endothelial-to-Mesenchymal Transition. Mol Cell. 2018; 69: 689–98. DOI: 10.1016/j.molcel.2018.01.010
. Medici D., Potenta S., Kalluri R. Transforming growth factor-β2 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling. Biochem. J. 2011; 437: 515–20.
. Yang Y., Cha B., Motawe Z.Y. et al. Ve-cadherin is required for lymphatic valve formation and maintenance. Cell Rep. 2019; 28: 2397–412. DOI: 10.1016/j.celrep.2019.07.072
. Топчий И.И., Кириенко А.Н., Тверетинов А.Б. и др. Содержание VE кадгерина в крови больных хроническим гломерулонефритом в сочетании с ишемической болезнью. 2012; 10 (129): 79–83. [Topchiy I.I., Kirienko A.N., Tveretinov A.B. and others. The content of VE cadherin in the blood of patients with chronic glomerulonephritis in combination with coronary heart disease. Current problems of medicine. 2012; 10 (129): 79–83 (In Russ.)]
. Braun L.J., Zinnhardt M., Vockel M., Drexler H.C., Peters K., Vestweber D. VE-PTP inhibition stabilizes endothelial junctions by activating FGD5. EMBO Rep. 2019; 20 (7): e47046. DOI: 10.15252/embr.201847046
. Gotsch U., Borges E., Bosse R., Böggemeyer E., Simon M., Mossmann H., Vestweber D. VE-cadherin antibody accelerates neutrophil recruitment in vivo. J. Cell. Sci. 1997; 110 (5): 583–8. DOI: 10.1242/jcs.110.5.583.
. Балацкий А.В., Чотчаева Ф.Р., Иванов А.Д., Самоходская Л.М., Ткачук В.А. Полиморфизм гена Т-кадгерина (CDH13) ассоциирован с характером манифестации ишемической болезни сердца. Вестник РГМУ. 2016; 1: 25–31. DOI: 10.24075/brsmu.2016-01-04. [Balatsky A.V., Chotchaeva F.R., Ivanov A.D., Samokhodskaya L.M., Tkachuk V.A. Polymorphism of the T-cadherin gene (CDH13) is associated with the nature of manifestation of coronary heart disease. Bulletin of RGMU. 2016; 1: 25–31 (In Russ.)]
. Квиткова Л.В., Бородкина Д.А., Груздева О.В. и др. Уровень лептина, адипонектина и свободных жирных кислот у пациентов с различной массой тела на фоне инфаркта миокарда с подъемом сегмента ST. Проблемы эндокринологии. 2013; 59 (3): 8 12. [Kvitkova L.V., Borodkina D.A., Gruzdeva O.V. and others. Levels of leptin, adiponectin and free fatty acids in patients with different body weights against the background of myocardial infarction with ST segment elevation. Problems of endocrinology. 2013; 59 (3): 8 12. (In Russ.)]
. Denzel M.S., Scimia M.C., Zumstein P.M. et al. T-cadherin is critical for adiponectin-mediated cardioprotection in mice. J. Clin. Investig. 2010; 120: 4342–52. DOI: 10.1172/JCI43464.
. Lou X., Zhao M., Fan C., Fast V.G., Valarmathi M.T., Zhu W., Zhang J. N-cadherin overexpression enhances the reparative potency of human-induced pluripotent stem cell-derived cardiac myocytes in infarcted mouse hearts. Cardiovasc Res. 2020; 116 (3): 671–85. DOI: 10.1093/cvr/cvz179
. Yan W. N-Cadherin Overexpression Mobilizes the Protective Effects of Mesenchymal Stromal Cells Against Ischemic Heart Injury Through a β-Catenin-Dependent Manner. Circ Res. 2020; 126 (7): 857–74. DOI: 10.1161/CIRCRESAHA.
. Tsai Y.W., Tseng Y.S., Wu Y.S., Song W.L., You M.Y., Hsu Y.C., Chen W.P., Huang W.H., Chng J.C., Lim C.L., Wei K.H., Ben Lai S.L., Lee W.C., Yang K.C. N-Cadherin promotes cardiac regeneration by potentiating pro-mitotic β-Catenin signaling in cardiomyocytes. Nat Commun. 2025; 16 (1): 896. DOI: 10.1038/s41467-025-56216-y
. Liberale L., Puspitasari Y.M., Ministrini S. et al. JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study. Eur. Heart J. 2023; 44 (20): 1818–33. DOI: 10.1093/eurheartj/ehac641.
. Burnier L., Fontana P., Angelillo-Scherrer A., Kwak B.R. Intercellular communication in atherosclerosis. Physiology (Bethesda). 2009; 24: 36–44. DOI: 10.1152/physiol.00036.2008
. Kwak B.R., Mulhaupt F. et al. Altered pattern of vascular connexin expression in atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 2002; 22 (2): 225–30.
. Burnier L., Fontana P., Angelillo-Scherrer A., Kwak B.R. Intercellular communication in atherosclerosis. Physiology (Bethesda). 2009; 24: 36–44. DOI: 10.1152/physiol.00036.2008..
. Савченко С.В., Новоселов В.П., Морозова А.С. и др. Оценка выраженности экспрессии коннексина 43 в миокарде при острой ишемии в эксперименте. Патология кровообращения и кардиохирургия. 2017; 21 (1): 81–90. [Savchenko S.V., Novoselov V.P., Morozova A.S. et al. Evaluation of the expression of connexin 43 in the myocardium during acute ischemia in the experiment. Circulatory pathology and cardiac surgery. 2017; 21 (1): 81–90 (In Russ.)]
. Li M., Wang Z., Shao J., Li S., Xia H., Yu L., Hu Z. Captopril Attenuates the Upregulated Connexin 43 Expression in Artery Calcification. Arch Med Res. 2020; 51 (3): 215–23. DOI: 10.1016/j.arcmed.2020.02.002.
. Балацкий А.В., Андреенко Е.Ю., Самоходская Л.М. и др. Полиморфизм генов эндотелиальной NO-синтазы и коннексина-37 как фактор риска развития инфаркта миокарда у лиц без коронарного анамнеза. Терапевтический архив. 2013; 85 (9): 18 22. [Balatsky A.V., Andreenko E.Yu., Samokhodskaya L.M. et al. Polymorphism of the endothelial NO synthase and connexin-37 genes as a risk factor for the development of myocardial infarction in individuals without a coronary history. Therapeutic archive. 2013; 85 (9): 18–22 (In Russ.)]
. Проничева И.В., Ревишвили А.Ш. Роль коннексинов и натриевого канала Nav1.5, кодируемого геном SCN5A, в нарушениях проведения электрического импульса в миокарде. Вестник аритмологии. 2012; 67: 59–62. [Pronicheva I.V., Revishvili A.Sh. The role of connexins and the sodium channel Nav1.5, encoded by the SCN5A gene, in disorders of electrical impulse conduction in the myocardium. Bulletin of Arrhythmology. 2012; 67: 59–62 (In Russ.)]
. Wen D., Du X., Nie S. P., Dong J. Z., Ma C. S. Association of Connexin37 C1019T with myocardial infarction and coronary artery disease: a meta-analysis. Experimental Gerontology. 2014; 58: 203–7.
. Liao M., Chen L., Lu J. et al. Connexin 37 Regulates the Kv1.3 Pathway and Promotes the Development of Atherosclerosis Mediators Inflamm. 2022: 2689918.
. Митева А.С., Гайдуков А.Е., Шестопалов В.И., Балезина О.П. Роль паннексина 1 в пуринергической регуляции синаптической передачи в моторных синапсах мыши Биологические мембраны. 2017; 34 (4): 48–57. [Miteva A.S., Gaidukov A.E., Shestopalov V.I., Balezina O.P. The role of pannexin 1 in purinergic regulation of synaptic transmission in mouse motor synapses Biological membranes. 2017; 34 (4): 48–57 (In Russ.)]
. Good M.E., Young A.P., Wolpe A.G., Ma M. et al. Endothelial Pannexin 1 Regulates Cardiac Response to Myocardial Infarction. Circ Res. 2021; 128 (8): 1211–3. DOI: 10.1161/CIRCRESAHA.120.317272.
. Барбараш О.Л., Байракова Ю.В., Понасенко А.В. и соавт. Роль полиморфизмов генов-кандидатов IL-β в возникновении инфаркта миокарда и формировании мультифокального атеросклероза у пациентов с ИБС Атеросклероз. 2016; 12 (3): 5–14. [Barbarash O.L., Bayrakova Yu.V., Ponasenko A.V. et al. The role of IL-β candidate gene polymorphisms in the occurrence of myocardial infarction and the formation of multifocal atherosclerosis in patients with coronary artery disease. Atherosclerosis. 2016; 12 (3): 5–14 (In Russ.)]
. Kim S.C., Neogi T., Kang E.H., Liu J., Desai R.J., Zhang M., Solomon D.H. Cardiovascular Risks of Probenecid Versus Allopurinol in Older Patients With Gout. J. Am. Coll Cardiol. 2018; 71 (9): 994–1004. DOI: 10.1016/j.jacc.2017.12.052.
. Хабибулина М.М., Баженова О.В., Шамилов М.Д. Обзор современных исследований по микроваскулярной стенокардии. Врач. 2024 (2): 64–69. doi:10.29296/25877305-2024-02-12. [Khabibulina M.M., Bazhenova O.V., Shamilov M.D. Review of modern research on microvascular angina. Vrach. 2024 (2): 64–69. doi:10.29296/25877305-2024-02-12 (in Russian)].
