Search

Molecular predictors of efficacy of single-stranded yeast RNA and ascorbic acid complexes: from critical quality attributes to personalized immunomodulation

Potupchik T.V., Ermolaev V.V., Generalov S.V., Alikin Yu.S., Evert L.S., Kurbanova D.V., Shevchuk A.S., Omarova L.S.

Introduction. Single-stranded yeast RNA–ascorbic acid complexes are of interest as a class of natural immunomodulatory systems combining activation of innate immune pattern-recognition receptors with redox-modulating and epigenetic effects of vitamin C. Russia…

YEAST RNA AS A SOURCE OF IMMUNOMODULATORY NUCLEOTIDES: FROM BIOCHEMISTRY TO CLINICAL APPLICATION

Potupchik T.V., Alikin Yu.S., Generalov S.V., Ermolaev V.V., Kudlay D.A., Ksanaeva J.A., Banar L.S., Makhova A.A.

Introduction. Yeast RNA is considered a promising class of natural immunomodulators that has been studied in Russian biomedical science since the Soviet period. High-molecular-weight RNA fractions from Saccharomyces cerevisiae exhibit pronounced immunostimulat…

THE INVOLVEMENT OF GLUTAMATE AMPA RECEPTORS IN THE REGULATION OF T-CELL ADHESION IN MULTIPLE SCLEROSIS

Tukhvatullin A.V., Kuzmina U.S., Bakhtiyarova K.Z., Vakhitova Yu.V.

Introduction. Glutamate receptors are involved in modulating key T-lymphocyte functions, including proliferation, chemotaxis, and others. In the context of the immunopathogenesis of multiple sclerosis (MS), studying the mechanisms underlying these effects is o…

Molecular patterns of RNA pathogens and immune response to exogenous RNA: recognition mechanisms and therapeutic potential

Potupchik T.V., Alikin Yu.S., Generalov S.V., Ermolaev V.V., Pluzhnikova A.V., Ferzilaeva N.R., Kozarenko M.A.

Introduction. Innate immunity represents the first line of defense against pathogens, based on recognition of conserved molecular patterns (PAMPs) through specialized pattern recognition receptors (PRRs). RNA-containing viral patterns are of particular importa…

Immunopathology of trauma: relationship between physical damage to the musculoskeletal system and the development of rheumatic diseases

Karateev A.E., Polishchuk E.Yu.

Introduction. A physical injury triggers a cascade of pathological processes, including the activation of the immune system and the development of local inflammation. Hereditary predisposition, pronounced structural changes, biomechanical disorders, and comorb…

Synergism of ascorbic acid and RNA interferon inducers in antiviral immunity activation: molecular mechanisms and therapeutic perspectives

Potupchik T.V., Alikin Yu.S., Generalov S.V., Evert L.S., Tymchuk V.I., Khalakoeva D.A., Abdullaeva S.R., Spitsyn А.А

Introduction. Ascorbic acid (vitamin C) is an essential cofactor of numerous enzymatic reactions and possesses pronounced antioxidant properties. Recent years have seen accumulating evidence of its immunomodulatory effects, particularly the ability to potentia…

Serotonin as a modulator of neurogenesis processes in post-traumatic stress disorder

The purpose of this review is to discuss the role of serotonin in the processes of neurogenesis in the hippocampus in post-traumatic stress disorder. Full-text materials were searched in Medline (PubMed) and Scopus databases over the past 15 years. Results. Co…

The Impact of Genetic Polymorphisms in Toll-like Receptor Genes on Interaction with Helicobacter pylori

Baratova I.V., Bodunova N.A., Deeva T.A., Bordin D.S., Chebotareva M.V., Tsapkova L.A.

The aim of the study. To describe the interaction between Helicobacter pylori and Toll-like receptors, and to outline the role of TLRs gene polymorphisms in the pathogenesis of this infection. Material and methods. An analysis of publications from 2000 to 2025…

Immunohistochemical study of somatostatin and dopamine receptors (SSTR2, SSTR5, DR2) in pituitary adenomas to justify targeted therapy

Guseva K.A., Paltsev A.A., Mitrofanova L.B.

Introduction. Adenomas are the most common disease affecting the pituitary gland. Most of these tumors can be successfully treated. The main method is transsphenoidal resection. The exception is prolactinomas, which are treated with dopamine agonists. Objectiv…

The Role of P2X7 Receptors in the Pathogenesis of Depression and Autism Spectrum Disorders

Panyukov V.A., Zakharova V.A., Malinovskaya N.A., Shogenov Z.I., Nicheporenko Yu.A., Shikhmagomedova A.R.

Introduction. Purinergic signaling pathways in brain cells can play an important role both in physiological conditions and in depression and autism spectrum disorders. The purpose of this literature review was a systematic analysis of information in the modern…

Features of local synthesis of neurotrophic factors under the influence of fractal stimulation phototherapy in a model of retinal pigment epithelium atrophy on rabbit

Balatskaya N.V., Fadeev D.V., Zueva M.V., Neroeva N.V., Brilliantova A.G., Timofeev Yu.S.

Introduction. It is assumed that in degenerative diseases of the retina, photostimulation with fractal dynamics signals activates neuroplasticity, increasing the effectiveness of visual rehabilitation. Previously, we demonstrated the positive effect of fractal…

Molecular mechanisms and pharmacogenetic determinants of II–III generation antihistamines efficacy in allergic bronchial asthma: personalized therapy prospects

Borodulina E.A., Yakovleva E.V., Borodulin B.E., Gladunova E.P., Marchenko S.D., Krylova O.V., Mamontova E.R., Rekalo A.R., Minnullina Z.R., Bagirova B.R., Salpagarova A.A.

Introduction. Allergic bronchial asthma (BA) is accompanied by activation of histamine H1/H4 receptors and variable response to antihistamines. The aim of this review is to analyze the molecular mechanisms of action of second- and third-generation antihistamin…

MECHANISMS OF STRUCTURAL FEATURES IN THE CEREBRAL CORTEX IN MODELS OF PREMATURE AGING OF NERVOUS TISSUE AFTER BACTERIAL LIPOPOLYSACCHARIDE

Venediktov A.A., Kuzmin E.A., Pokidova K.S., Oganesyan D.M., Stepanian A.T., Boronikhina T.V., Piavchenko G.A., Kuznetsov S.L

Introduction. Many chemical compounds affect brain neurons differently than other cell populations. This is provided by the protective potential of the blood-brain barrier (BBB). One of the compounds capable of passing through the BBB is bacterial lipopolysacc…

NEUROTROPIC EFFECTS OF ENDOGENOUS COMPOUNDS – TYRONOME COMPONENTS IN THE CENTRAL NERVOUS SYSTEM

Kudlay D.A., Filimonov D.A., Morozov V.V., Ishchenko R.V., Eresko A.B., Trubnikova N.N., Belotserkovskaya M.A., Kisilenko I.A., Nosova I.N.

Background. During the last decades, data on potential cytoprotective effects of decarboxylated and deiodinated endogenous compounds – metabolites of thyroid hormones, constituting the thyronome, have been accumulated. The aim of this review is to systematize …

COMPUTER PREDICTION OF PHARMACOLOGICAL ACTIVITY OF SOLANUM TUBEROSUM L. ALKALOIDS

Voronov V.A., Daironas J.V., Zolotykh D.S.

The alkaloids solanine and chaconine were discovered in 1821. However, its did not find medical use due to toxicity. At present, modern research methods have revealed anti-cancer activity of the alcaloids. In this regard, the hypothesis of the presence of othe…

Genetic predictors of the risk of developing complications in the immediate postoperative period following combat trauma

Kishenya M.S., Sobolev D.V., Anchikova E.V., Visyagin A.V.

Introduction. Paratraumatic eczema (PTE), being a type of microbial eczema, occurs after surgical interventions, chronic wound healing, accompanied by pronounced inflammatory changes with hyperemia, edema, exudation, soreness and itching. Genetic polymorphisms…

Individual trombocity reactivity in hematuria associated with nephrolitiasis: the role of purinergic signalisation in the treatment of nesteroid protective preparations

Barinov E.F., Yureva A.S., Akhundova S.A., Giller D.I.

Aim of the study was to establish the significance of TR-receptor, P2X1-receptor and P2Y-receptor synergism for the efficiency of TC aggregation in patients with different sensitivity to non-selective NSAIDs, which will allow us to approach an understanding th…

EVALUATION OF THE EFFECT OF NEUROPEPTIDES OF THE MELANOCORTIN FAMILY ON STRESS-ASSOCIATED CHANGES IN THE LEVEL OF CORTICOTROPIN-RELEASING HORMONE AND CORTICOSTERONE

Yasenyavskaya A.L.

Introduction. To date, the problem of studying the neuropeptide system of regulation of adaptive processes is relevant, since the stress reaction is a trigger for the occurrence of various diseases, in particular depression. Corticoliberin is considered as the…

Effect of the dipeptide retro-analog of cholecystokinin tetrapeptide (GB-115) on the behavior of rhesus monkeys in isolation

Panchenko Al.V., Panchenko An.V., Pavlova L.E., Timina M.F., Cherkashina E.V., Kolik L.G., Seredenin S.B.

Introduction. The developed domestic dipeptide retro-analog of cholecystokinin (CCK) tetrapeptide (N-(6-phenylhexanoyl)-glycyltryptophan amide, compound GB-115) with antagonistic properties towards CCK1 receptors has anxiolytic activity, previously shown in pr…

ANALYSIS OF MODERN CONCEPTS OF NEURODEGENERATIVE PROPERTIES OF DEPRESSION

Yasenyavskaya A.L., Tsibizova A.A., Samotrueva M.A.

Introduction. The review is devoted to the analysis of modern concepts of the neurodegenerative properties of depression. Depression is now regarded as the most common mental illness with significant social consequences. The aim of the study is to determine th…