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Molecular Medicine
Found: 369
The pathogenetic process of sarcopenic obesity (SO) development is multifactorial, the key of them is considered – non-specific systemic inflammation. Objective. to assess the influence of the intensity of the course of chronic inflammation in patients with ty…
Introduction. Innate immunity represents the first line of defense against pathogens, based on recognition of conserved molecular patterns (PAMPs) through specialized pattern recognition receptors (PRRs). RNA-containing viral patterns are of particular importa…
Currently, there is no existing data on the role of asprosin and meteorin-like protein (Metrnl) in the pathogenesis of obesity in children. Purpose of the study. To assess the relationship between the levels of adipomio-cins asprosin and Metrnl with body compo…
Background. University entry is accompanied by abrupt changes in social environment, lifestyle and cognitive load, which challenge stress-response systems, the autonomic nervous system (ANS), and immune-metabolic homeostasis. In Russian clinical practice, this…
Introduction. A physical injury triggers a cascade of pathological processes, including the activation of the immune system and the development of local inflammation. Hereditary predisposition, pronounced structural changes, biomechanical disorders, and comorb…
The aim of this review is to systematize current knowledge on the role of selenium in biochemical processes and in the development of diseases associated with its deficiency or excess. Material and methods. A comprehensive search and analysis of publications f…
Introduction. To date, digital twins are the most promising area for the development of modern healthcare. With their help, it is possible to radically change approaches to the diagnosis, treatment and prevention of diseases. In medicine, the concept of digita…
Introduction. Ascorbic acid (vitamin C) is an essential cofactor of numerous enzymatic reactions and possesses pronounced antioxidant properties. Recent years have seen accumulating evidence of its immunomodulatory effects, particularly the ability to potentia…
Introduction. Short peptides are considered a promising class of geroprotective agents capable of modifying key molecular mechanisms of aging, from epigenetic regulation of gene expression to maintenance of neuroendocrine and antioxidant homeostasis. Laborator…
This review was conducted to systematize data on the association of matrix proteinase gene polymorphisms (MMP, ADAMTS, ADAM) with the risk of developing osteoarthritis. Material and methods. A systematic literature search of PubMed and Web of Science databases…
Relevance. Primary malignant neoplasms of bones and articular cartilage account for about 0.2% of all cancer cases and are characterized by an aggressive course, high tendency to metastasize, and resistance to therapy, which leads to unsatisfactory survival ra…
Аmphocyte production and indirectly reflect the state of the adaptive immune system. Their concentration in dried blood spots can be determined by quantitative polymerase chain reaction (qPCR). Currently, these markers are used for neonatal screening of primar…
The aim of the study. To describe the interaction between Helicobacter pylori and Toll-like receptors, and to outline the role of TLRs gene polymorphisms in the pathogenesis of this infection. Material and methods. An analysis of publications from 2000 to 2025…
Introduction. Chronic non-communicable diseases (NCDs) account for 75% of global mortality, while traditional treatment paradigm demonstrates inability to contain epidemiological burden. Artificial intelligence (AI) technologies combined with telemedicine enab…
Introduction. Thanks to the achievements of modern medicine, it was possible to significantly increase the life expectancy of the population. Molecular mechanisms of aging include telomere shortening, DNA damage accumulation, mitochondrial dysfunction, leading…
Introduction. Rabies is currently a rare but deadly viral disease transmitted through animal bites, mainly dogs. There is no standardized effective therapy for clinically manifest rabies. Patients with developed symptoms are mainly provided with palliative car…
Introduction. To date, there are a number of relevant studies devoted to changes in the LPO-AOP system indicators in adolescents and young adults with migraine. However, specific quantitative data and relationships between LPO-AOP indicators and migraine requi…
Introduction. Purinergic signaling pathways in brain cells can play an important role both in physiological conditions and in depression and autism spectrum disorders. The purpose of this literature review was a systematic analysis of information in the modern…
Introduction. Neurotoxicity is a common complication of chemotherapy that negatively affects the quality of life of cancer patients. Damage to the nervous system affects both the peripheral nerves (peripheral neuropathy) and the central nervous system (chemo b…
Introduction. Leptin is a representative of biologically active compounds produced by adipose tissue – adipokines. The traditional material for his research is blood. Saliva is a local secret of the glands of the initial part of the digestive tract, which has …