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Molecular Medicine
Found: 59
Gestosis is a complication of the normal course of the gestational process that occurs during pregnancy, childbirth and in the first days of the postpartum period, characterized by a deep disorder of the functions of vital organs and systems. Preeclampsia (PE)…
Aim of investigation. The study of characteristics of fibroblast growth factors (FGFs), as a man factor FGFd, including 22 structurally connected polypeptides, is necessary for the neuroprotection by the CNS degenerative pathology is presented playing a great …
Introduction. The creation of peptide bioregulators that contribute to the preservation of the basic physiological functions of the body is an urgent task of modern biology and medicine. The aim of the study was to evaluate the effect of polypeptide complexes …
The senescence-associated secretory phenotype (SASP) is one of the causes of age-associated diseases, including atherosclerosis. The purpose of the review is to analyze data on the role of SASP cells of the cardiovascular system in the pathogenesis and pharmac…
Introduction. Oxidative stress and mitochondrial dysfunction are observed in virtually any disease associated with premature aging. Signaling molecules produced by mitochondria can act as specific targets for the action of pharmacological agents in order to re…
Introduction. Mitochondria are one of the most important cellular organelles that provide cells with energy, take part in cellular renewal and the implementation of endogenous mechanisms of cellular immunity. The study of the structural and functional organiza…
Introduction. Early diagnostics of such oncological disease as cutaneous malignant melanoma is strictly important for the decrease of mortality. It is known that microRNA expression in melanoma cells and in bening melanocytic nevi is different, that can be use…
Recently, the involvement of histamine in the regulation of the function of cells in the immune system has been actively studied, including the ability of the mediator to modulate inflammatory responses of different cell types to infectious agents by activatin…
The review presents literature data that reveal the mechanism of mutual influence of microbiota and melatonin in the unified system «mother–placenta–fetus». There is shown the variety of functions performed by the microbiota, provided by the presence of commun…
At present biomedical research is based on joint fulfillment of theoretical and experimental investigations of various derivatives of potential therapeutic destination. Well-balanced combination of noted studies is provided for the high reliability of ensemble…
The review summarizes a number of published reports about the influence of total hormonal and metabolic disturbances on the functioning system mother – placenta – fetus in the organism of the women with obesity and gestational diabetes mellitus. The circadian …
Introduction. The decline in collagen I type synthesis and the gain in matrix metalloproteinases (MMPs) activity are the main characteristics of the molecular skin aging. MMPs are ferments which cleave collagen. The aim of the study was to investigate the infl…
The problems of longevity increase and its quality improvement are actual for the modern gerontology. So far it is necessary to complete tasks of early diagnostic and target prophylactic of the age-associated pathology. There are presented the data concerning …
Introduction. Influence of environmental hazards on pregnant women or development of pregnancy in presence of pathogenic pathway may lead to miscarriage, teratogenic effects and/or significant abnormalities in physical development, cognitive and behavioral sta…
Peptidergic structures of the hypothalamus arrange a basis of its unique ability to regulate the organism's functions in time, adjusting metabolism, energy exchange and motor activity as sources of its own energy- to the dynamics of energy intake from external…
Introduction. Excess and lack of adipose tissue are associated with a violation of its functions, the mass of adipose tissue and its distribution play an important role in the development of metabolic disorders. The study of the influence of the main factors o…
Dendritic cells (DC), as professional antigen-presenting cells with functional plasticity, are widely studied in preclinical and clinical research of vaccines against various types of malignant tumors. Some of the studies DС have proved their efficiency. Howev…
Introduction. Vitamin D is one of the main regulators of phosphorus-calcium metabolism. Vitamin D availability is determined by both external and genetic factors. The genetic contribution to the 25 (OH) D level is estimated to range from 23 to 77%. According t…
There are presented data about rejuvenating mesencephalic astrocyte-derived neurotrophic factor (MANF) and its physiological functions. This is a new neurotrophic factor, produced by the mesencephalic astrocytes and it is different from other factors by its ac…
This article provides a modern analysis of the literature on the mechanisms of activation of mast cells (MC) because they are regulatory cells that make up an important part of the immune system and are part of the first line of defense against various patholo…