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Molecular Medicine
Found: 62
Aim. Comparative evaluation of FcγRIIIb (CD16) expression level on the surface of blood neutrophils in vaccinated and unvaccinated people before and after the interaction of сells in vitro with the plague microbe allergen (pestin). Materials and methods. Blood…
Introduction. New directions of the modern cell biology are the development of methods for reprogramming stem cells into differentiated ones and reverse reprogramming of differentiated cells into stem cells. Transient processes in cells from the one stable sta…
Introduction. Dyes have long been successfully used in medicine as exogenous chromophores to increase the effectiveness of the interaction of light with biological tissues, as contrast agents and photosensitizers in diagnosis and photodynamic therapy. At prese…
Introduction. The initial state of an organism and its initial reactivity are the main prognostic criteria for the individual radiosensitivity evaluation. Particulars of the DNA structure and chromatin conformation determine in many respects the cell radiosens…
Introduction. The difference in the responsibility of organisms’ influences on the results of biological experiments and medical intervention. The chromatin conformational state is one of the main factors determining the cell response to the effect of differen…
Introduction. Skin aging is a natural process that cannot be stopped. However, there are many ways to help stop premature aging of the skin and reduce the signs that have already appeared. One of them is the subcutaneous administration of preparations containi…
Introduction. Application of placenta hydrolysate in cosmetology opens a new page in anti-aging therapy. Numerous studies have confirmed the antioxidant, anti-inflammatory, anti-pigmental properties of placenta hydrolysate preparations, as well as activation o…
Aging is a complex biological process, the main aspect of which is the accumulation of somatic changes in the body during life. Late reproductive age is associated with infertility and possible complications of pregnancy. Aging at the cellular and organ levels…
Introduction. Her2/neu is one of the most studied molecular target the overexpression of which is associated with poor prognosis and aggressive course of the disease. The use of modern non-invasive radionuclide techniques with the application of highly affinit…
The review of the literature on suicide gene therapy is presented. The therapeutic method is based on the transfection of tumor cells with a construct including the gene of the enzyme converting the substrate – the prodrug demonstrating low toxicity into a hig…
Among the injuries of the central nervous system, a special place is occupied by injuries of the spinal cord (SC), which are still practically resistant to treatment and cause severe consequences. Necrosis of the tissue – the immediate consequence of the mecha…
Introduction. The article is devoted to the actual medical and social problem of modern reproductive medicine – new approaches to improve and regenerate the implantation susceptibility of the endometrium in infertility. Currently, in addition to traditional ho…
Aim. The study of the angiotropic activity of dipeptide mimetics of the nerve growth factor (NGF) loop 4 possessing properties of TrkA receptor agonists and antagonists. Methods. Experiments in vitro. Angiotropic effects of dipeptide mimetics of the NGF loop 4…
Introduction. The investigation of molecular and cellular mechanisms of atherosclerosis and the development of restenosis and the possibility of the regulation of these processes by short peptides opens new perspectives for the delivery of vasoprotective prepa…
Introduction. The minor population of Sertoli cells (SCs) from the transitional zone (TZ) of adult mouse testis called as TZ SCs is capable of active proliferation in culture and, at the same time, expresses all key SC markers. It could be an optimal source of…
The data concerning the changes of expression and posttranslational modification of the human protein under the influence of the external and internal irradiation in vivo and in vitro are presented in this review. The investigation of protein expression and po…
The review presents data concerning the interaction of basic types of nanoparticles with human platelets in vitro and in vivo and biological results of this influence. The initial structure of nanoparticles and their biologically active cargo can both stimulat…
ntroduction. Agr2protein belongs to the family of disulfide isomerases of the endoplasmic reticulum and contains active cysteine domains involved in the formation of disulfide bonds with mucins. It is expressed in goblet cells of the intestinal epithelium and …
Purpose an experimental evaluation of the effectiveness of new hydrogels based on hyaluronic acid and chitosan succinate as an agent of mitomycin C (MMC) for glaucoma surgery. Material and methods. Synthesis of hydrogel drainage (HD): The required amount of MM…
Introduction. At the present time the attention to the development of implant coating is growing in the fields of surgery, odontology, traumatology and orthopedy because of its possibility to improve the stability of metal implants on the one hand and to provi…