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Molecular Medicine
Found: 29
Introduction. The scale of myocardial infarction plays a key role in the prognosis of the disease. Changes in contractile activity of myocardial tissue as a result of necrosis of cardiomyocytes is the decisive factor in this issue. The aim of the study. The pu…
Introduction. Leiomyomas also called fibroids, is the most common benign gynecological tumor in premenopausal women. The complex pathogenesis shows multiple biogenetical and multifactorial aspects to influence the etiology and growth of leiomyomas. A clinical …
Epigenetics studies inherited mechanisms capable of modulating gene expression without altering the DNA nucleotide sequence. Until very recently, epigenetics included inherited mechanisms, such as DNA methylation and histone modification. As of today, a large …
Introduction. Alcoholic cardiomyopathy is the leading cause of death in persons withchronic alcoholism. This disease is caused by ethanolinduced toxic damage to the heart muscle, which leads to dilated heart failure and the development of the electric myocardi…
Introduction. Uterine fibroids – a benign tumor, growing from immature muscle cells of the vascular wall of the uterus. It ranked first among the benign tumors of the genital organs, with one in ten suffers from gynecological patients with uterine myoma. The a…
Introduction. The ACTA2 gene encodes α-actin in aortic smooth muscle cells, and its mutations may cause thoracic aortic aneurysms. Analysis of ACTA2 polymorphism can be used in a complex risk assessment of non-familial thoracic aortic aneurysms. The aim of the…
Introduction. Mutations in the tumor suppressor gene TP53 are observed approximately in the half of all human malignancies. In bladder cancer (BC), ТР53 molecular alterations were shown to be associated with more aggressive tumor phenotype; however their clini…
Introduction. Due to the impetuous development of endovideosurgery in gynecology, laparoscopic access technique is increasingly frequently used to perform myomectomy. However in the available literature until now there is no decisive opinion on the feasibility…
Pre-metastatic niche formation precedes tumor dissemination although the mechanisms of it remain unclear. Therefore, the aim of the study was to evaluate the expression of molecules characterizing the microenvironment remodeling in target organs lungs and live…