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Molecular Medicine
Found: 37
Introduction. The aim of this study to determine carrier frequencies of polymorphic markers G1846A (CYP2D6*4) and C100T (CYP2D6*10) of the CYP2D6 gene in coronary heart disease (CHD) patients in Russian and Yakut ethnic groups. The association between theadmin…
ntroduction. The aim of this study was to determine the prevalence rate of CYP2C19 alleles, associated with the risk of the resistance to clopidogrel and the development of thrombotic complications in patients with acute coronary syndrome (ACS) from Russian an…
Currently, tuberculosis is the second leading cause of death from an infectious agent in the world and an important social and medical-biological problem. The first-line drug isoniazid is one of the most effective antituberculosisdrug, however it has a wide sp…
Introduction. Currently questions on the role of genes polymorphism that regulate metabolism and implicated in metabolic disorders are disputed. Objective. The study of proteomic and metabolomic manifestations of different variants of apolipoprotein E genes po…
Introduction. Valvular calcification precedes the development of valvular stenosis. Currently, there being no way to effectively prevent the valvular heart disease progression, and valve replacement remains to be the only treatment option. Aim. To investigate …
In the context of the continuing importance of the problem of tuberculosis there must be the selection both of priority areas to combat it, and priority category of patients. The most common form of TB among new cases is infiltrative and successful treatment o…
Introduction. Atherosclerosis, manifesting itself as acute coronary syndrome, stroke, and peripheral artery disease, is a chronic progressive inflammatory disease driven by both innate and adaptive immunity. As Triggering Receptor Expressed on Myeloid Cells-1 …
Introduction. Binding of the human immunodeficiency virus (HIV) envelope gp120 glycoprotein to CD4 and CCR5 receptors on the cell membrane initiates the viral entry process. Simultaneous expression of these two receptors has been observed on T-lymphocytes, mon…
Introduction. Chemokines are a group of proteins that plays an active role in the regulation of the vascular wall inflammation during the development of essential hypertension. The aim of the study was to investigate an association between essential hypertensi…
Introduction. According to inflammatory theory of atherosclerosis the immune damage of arteries with an autoimmune component – is the main link of its pathogenesis. The imbalance of cytokines production influences on course and prognosis of atherosclerosis. As…
Introduction. Although the interrelationship between disorders of the skeletal system with chronic gastroduodenitis (HGD) and infection with Helicobacter pylori (HP) currently has been well-studied in the literature practically there are no data reflecting the…
Introduction. Rett syndrome (RTT) is the most common genetic syndrome underlying mental retardation and autism in girls. Etiology of this disorder is related to mutation in the MECP2 gene. However, there are many cases of this disease without the MECP2 mutatio…
Introduction. Diagnosis of genomic and chromosomal anomalies is based on the application of cytogenetic and molecular technologies. The aim of the study. The objective of the work was the delivery and the use of the algorythm for diagnosis of structural genomi…
Genomic and molecular genetic studies of autism can identify new biological markers to determine the etiology and the molecular and cellular mechanisms of the pathogenesis of this disease. In addition to the fundamental importance of this research the laborato…
Staphylococcus aureus is a common human pathogen. In the past few decades, infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have become a global problem. MRSA is resistant to all β-lactam antibiotics, except anti-MRSA cephems, and is one…
The associations of polymorphic markers of the xenobiotics – metabolizing genes (GSTТI, GSTМI, GSTPI), cell cycle regulation genes (ТР53,CDKNI) and of the gene XRCCI repairing damaged DNA bases in 54 healthy subjects and 50 patients with upper respiratory trac…
Background. Congenital heart defects can be embryopathies formed due to an imbalance in the processes of differentiation and proliferation in cardiac progenitor cells. One of the reasons for these disorders may be genetically restricted signaling, including th…