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Molecular Medicine
Found: 248
The most important event in the molecular biology of the last years is the discovery of the regulation of intracellular processes by micro RNAs – a product of complicated processing of precursor RNAs synthesized on nuclear genes, that are playing the key role …
Introduction. Activation of eNOS/sGC/cGMP-pathway is a common link in the development of angiogenic action of the majority of pro-angiogenic factors. In this regard, the chemical inhibition of NOS (Nitric Oxide Synthase) may cause a nonspecific angiostatic eff…
Prediction of clinical outcome of breast cancer (BC) is a multi-level process that includes the clinical and anatomical assessment both of the disease and the expression levels of proteins, DNA and RNA. This article discusses the application of traditional and…
Neuroendocrine tumors (NETs) constitute a heterogeneous group of relatively rare neoplasms, incidence of which has increased in the last decades. These tumors are composed of cells with a neuroendocrine phenotype and may occur in any organ, but are most often …
Among oncology diseases the primary bone tumors make up to 0,7–2,0% of all malignancies. The peak of morbidity caused by bone tumors falls on the age of person’s social activity. Bone tumors are one of the most aggressive among malignant human tumors. That’s w…
Introduction. The study of growth factors in tissues of various kinds of nevi alongside with the skin melanoma can provide valuable information about the pathogenesis of the latter, determine the factors of early diagnostics of melanoma, as well as outline the…
Introduction. Pharmacogenetic testing allows of increasing efficacy of anticoagulation therapy, reducing time required for adjusting therapeutic dose, and considerably reducing number of complications. The aim of the study. To investigate the dependence of the…
Introduction. One of the most prospective approaches in therapy of deep skin burns is the development of artificial dermal equivalents with a potential to provide efficient scaffolding for dermis reconstruction and re-epithelisation. The choice of material for…
Introduction. In recent years among non-drug methods of treatment and rehabilitation of patients of elderly and senile age is a promising application of low-intensity millimeter waves as an important reserve of increasing the effectiveness of the complex thera…
Introduction. The prevalence of human cutaneous melanoma (CM) in the world is constantly rising. Diagnostics and treatment of CM at the early stages allows to increase the 5-year patient survival up to 90%. This problem can be solved with personalized therapy …
Lung cancer is one of the most common oncologic diseases in the world and the most frequent cause of the death from malignant neoplasms. Last decade’s studies revealed significant number of molecular events leading to the onset and development of non-small cel…
Introduction. Insulin-like growth factor signaling system plays a major role in the development and progression of various malignant tumors including ovarian cancer, and its components are considered as potential diagnostic and prognostic markers and objects o…
Introduction. Thymidylate synthase (TS) is a key enzyme in nucleotide biosynthesis and is the main intracellular target of 5-FU. We investigated the clinical and prognostic importance of TYMS gene 5' (TSR2/TSR3 and G>C) and 3' (del 6) untranslated region polym…
Introduction. P16INK4a protein plays one of the key role in processes of cell proliferation, its inactivation is noted in a number of tumors of various localization. Restoration of the p16INK4a function in neoplastic cells may promote braking of division of tu…
Introduction. Skeletal involvement is a frequent and troublesome complication of breast malignant tumors. The accurate diagnosis of bone metastasis and well-timed prescription of the antiresorptive therapy are essential for reducing both severity and mortality…
Addictive substances, medication, and environmental substances can permanently disrupt fetal brain development, which might ultimately lead to learning difficulties as well as to many types of behavioral disorders in later life. Congenital defects of this kind…
Introduction. Endocrine factors are considered to be important in the etiology of spontaneous abortion. Aim of the study. Histological and immunohistochemical characterization of the expression of estrogen and progesterone receptors in the gravid endometrium d…
Introduction. The COMT gene encodes for a protein involved in deactivation of genotoxic estrogen species, and the protein product encoded by the L (low activity) allele is 3–5-fold less active than its counterpart encoded by the H (high activity) allele. The a…
Introduction. One of the main types of a hormonal therapy in the treatment of the cancer of the prostate gland is the antagonists of the NR3C4 (nuclear receptor subfamily 3, group C, member 4) receptor. It blocks binding of man’s hormones with receptors site, …
Introduction. A novel 3S-paradigm of alternative experimental anti-cancer drug testing procedure was developed in parallel with a modern conception of personalized and predictive medicine to reveal both positive and negative effect in each experiment and topre…