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Molecular Medicine
Found: 369
Introduction. The aim of this study to determine carrier frequencies of polymorphic markers G1846A (CYP2D6*4) and C100T (CYP2D6*10) of the CYP2D6 gene in coronary heart disease (CHD) patients in Russian and Yakut ethnic groups. The association between theadmin…
Introduction.The telomerase activity is a universal marker for 85% of malignant tumors. This allows us to develop modern highly sensitive and highly specific kits for the diagnosis of most malignant tumors, including early stages of the disease. Existing metho…
Introduction. The clinical use of the antitumor drug etoposide is associated with many side effects, limiting its application in the clinical practice. One of the ways to reduce the toxicity and increase the effectiveness of the action of etoposide can be its …
Purpose. To study pharmacokinetic parameters in studies of a comparative bioavailability in combination with the assessment of homeostatic mechanisms of the regulation on the example of calcium. Methods. There were studied pharmacokinetic parameters of calcium…
The aim of this work was to study the effect of methotrexate, glucocorticoids and nonsteroidal anti-inflammatory drugs on the plasma levels of nitric oxide metabolites, as well as the level of NOS2 gene transcripts in peripheral blood leukocytes (PBL) in rheum…
Introduction. Alcoholic cardiomyopathy is the leading cause of death in persons withchronic alcoholism. This disease is caused by ethanolinduced toxic damage to the heart muscle, which leads to dilated heart failure and the development of the electric myocardi…
Introduction. Changes in the structural organization of the cell nucleus often precede the degeneration of the nerve cell. Histone H4 trimethylated on lysine 20 (H4K20me3) may act as one of the markers of neurodegenerative processes. The aim of this paper was …
Introduction. Glycine is well-known to have a positive effect in the treatment of patients suffered from an ischemic stroke. Vasodilatation is one of the main parts of the action of this amino acid at the molecular level. Simultaneously, the increase of oxygen…
Introduction. Missed and spontaneous abortions are one of the most important causes of the reproductive loss. The aim of the study: to study specialties of mRNA expression of p53 and proteins of its signaling pathway in the decidual tissue at 6–10 weeks of ges…
Introduction. The use of cell technologies has particular effectiveness in the correction of the experimental venous thrombosis and acute local obstruction to the blood outflow. Autologic multipotent mesenchymal stromal cells of a bone marrow origin (AMMSCBMO)…
The prostate cancer (PCa) incidence rate rises steadily among males all over the world. Over the past twenty years, the prostate-specific antigen (PSA) definition level in the patient's blood has been used for the PCa non-invasive diagnostics. However, due to …
Aim of the study. To study trimetazidine cardioprotective effects on the translation model of alcoholic cardiomyopathy Materials and methods. Alcoholic cardiomyopathy was reproduced in white mongrel male rats used as the sole source of liquid 10% ethanol solut…
Introduction. The article is devoted to the actual medical and social problem of modern reproductive medicine – new approaches to improve and regenerate the implantation susceptibility of the endometrium in infertility. Currently, in addition to traditional ho…
Modern methods of treatment of Parkinson's disease (PD) remain to be unsuccessful in cessation of the progression of neurodegenerative processes in the brain. The role of certain genes is proven by the etiology of PD, 10–15% of cases represent a monogenic dise…
The review presents results of clinical and experimental investigations, revealed leptin’s role in the mechanisms of morphological and physiological development of the fetus and newborn. This review summarizes many of the published reports about the leptin’s r…
Aim. The study of the angiotropic activity of dipeptide mimetics of the nerve growth factor (NGF) loop 4 possessing properties of TrkA receptor agonists and antagonists. Methods. Experiments in vitro. Angiotropic effects of dipeptide mimetics of the NGF loop 4…
The aim of the study. This study was designed to explore relationships between the activation of signaling pathways triggered by a novel cardioprotective drug Metilin, on one hand, and the recovery of metabolic state and the membrane stability in cardiomyocyte…
Currently, tuberculosis is the second leading cause of death from an infectious agent in the world and an important social and medical-biological problem. The first-line drug isoniazid is one of the most effective antituberculosisdrug, however it has a wide sp…
The headache is an important medical and social problem. Currently, genetics is the least-studied component of the pathogenesis of primary headaches. The most common forms of primary headache include migraine, tension type headache, cluster headache. This arti…
Introduction. Low rate of the pregnancy frequency in the IVF programs is one of the challenges in gynaecology nowadays. One of the approaches to enhance the efficacy of the assisted reproductive technology is to estimate the success of the forthcoming procedur…