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Molecular Medicine
Found: 377
Introduction. Alcoholic cardiomyopathy is the leading cause of death in persons withchronic alcoholism. This disease is caused by ethanolinduced toxic damage to the heart muscle, which leads to dilated heart failure and the development of the electric myocardi…
Introduction. Myoma occupies a leading place in the structure of gynecological diseases, reduces the fertility rate and living standardsin females of reproductive age. In 85% cases myoma is combined with adenomyosis, which complicates the treatment and increas…
Introduction. The study of the prevalence of genetic risk factors for thrombosis-associated diseases in the indigenous population of Siberia is an important issue in current medicine. The aim of the study. The aim of this work is to study the allele frequencie…
The prostate cancer (PCa) incidence rate rises steadily among males all over the world. Over the past twenty years, the prostate-specific antigen (PSA) definition level in the patient's blood has been used for the PCa non-invasive diagnostics. However, due to …
Introduction. Uveal melanoma (UM) is a tumor of neuroectodermal origin developing from melanocytes of the uveal tract. The very common pathological characteristic of UM is its metastatic activity in liver, leading to the poor efficiency of the treatment. That`…
Introduction. Aproblem of finding of new markers of the development and progression of gastric cancer is actual. In this context, investigations on the role of proteolytic system sin this pathologyare gaining in importance. The aim of the study. The study of t…
Introduction. A possible pathogenesis for Crohn’s disease (CD) involves the provocation of uncontrollable immune response by intestinal microbiota. Escherichia coli is regarded as a candidate for possible pathogen, since its content is increased in intestine o…
Modern methods of treatment of Parkinson's disease (PD) remain to be unsuccessful in cessation of the progression of neurodegenerative processes in the brain. The role of certain genes is proven by the etiology of PD, 10–15% of cases represent a monogenic dise…
Introduction. Uveal melanoma (UM) is the most common primary intraocular tumor in adults. This type of cancer is characterized by the high metastatic activity in the liver, which is the crucial factor for 95% of patients’ bad outcome in any case of the treatme…
The headache is an important medical and social problem. Currently, genetics is the least-studied component of the pathogenesis of primary headaches. The most common forms of primary headache include migraine, tension type headache, cluster headache. This arti…
Parkinson’s disease (PD) is a progressive, age-related, neuronal disorder that affects as much as 1% of the persons over 65 years. According to forecasts of the World Health Organization over the world about 9 million people will suffer from PD by 2030. So PD …
The review considers the main trends of the new concept of individual health medicine, called the predictive preventive personalized participative medicine – P4 Medicine. Medico-biological and medico-social prerequisites for the development of personalized med…
Introduction. Endometrial hyperplasia represents a chronic progressive disease characterized by high prevalence among women in older age groups. The aim of the study. To study the involvement of combinations of candidate genes in the formation of hyperplastic …
Introduction. Carrier protein OATP1B1, encoded by the SLCO1B1gene, is involved in the transport of simvastatin into liver cells. SLCO1B1 gene polymorphisms influence on the functionality of the transporter, which could reflect on the efficacy and safety of tre…
Introduction. The physiological state of the skin vasculature is largely determined by the influence of environmental factors, including the alteration of the oxygen partial pressure. Obviously, the epidermis, as the surface layer of the skin, should play a ke…
Uveal melanoma (UM) is a rare, aggressive intraocular malignant tumor, leading to metastatic disease in more than 50% of patients. Cytogenetic and molecular studies have identified some genetic prognostic factors considered to be reliable to forecast the survi…
Introduction. Erysipelas is characterized by consistently high morbidity rate, pronounced tendency to recur, the frequent change of lymph circulation, formation of secondary elephantiasis and others symptoms. The prediction of the course of erysipelas is unres…
Introduction. Insulin-like growth factor (IGF) signaling system plays a major role in development and progression of various malignant tumors including colorectal cancer (CRC), so far its components are considered as potential diagnostic and prognostic markers…
Introduction. A lot of factors of innate and specific immunity are involved in development of the autoimmune diseases – multiple sclerosis (MS) that cause the damages of myelin envelopes of nerve fibres with irreversible neurological consequences. To decrease …
In acute focal ischemia of the heart and brain similar processes are developing despite the obvious differences in the structure, function, and blood supply of these organs. It was shown that under ischemic conditions synthesis stress induced proteins includin…