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Molecular Medicine
Found: 663
Introduction. Urological and genital malignant neoplasms in men are an urgent problem. Every year, about 403.3 thousand newly diagnosed cases of kidney cancer and 34.5 thousand of penile cancer are registered in the world. With metabolic atypism, a change in a…
Sarcopenia is a progressive and generalized pathology of skeletal muscles of multi-factor nature. The present review focuses on the analysis of molecular genetic markers that may contribute both to sarcopenia risk formation and the variability of diagnosticall…
The review presents literature data that reveal the mechanism of mutual influence of microbiota and melatonin in the unified system «mother–placenta–fetus». There is shown the variety of functions performed by the microbiota, provided by the presence of commun…
Introduction: nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. But it remains unclear what factors influence the progression of the disease. It is interesting to study the influence of the genetic aspect on the course of NAF…
Introduction. The cytostatics, inhibiting the cellular proliferation, are using in clinic for the inhibition of tumor development in patients. However, the adverse events can occur because of the damage of health cells of other tissues. A delay or decrease of …
Osteopontin (OPN) is a highly phosphorylated multifunctional glycosphoprotein with important functional activity in cancer and cardiovascular diseases, diabetes mellitus (DM), kidney and liver pathology, inflammatory process, and also influencing cell viabilit…
Introduction. Aging is associated with a decrease in the neuro- and synaptogenesis as well as hyperactivation of glial cells, which leads to changes in the morphofunctional state of the nervous tissue of the hippocampus and, as a consequence, a deterioration i…
Introduction. The oral cavity is the beginning of the human digestive system and the presence of pathological changes in it: a shift in the dynamic balance, composition, and types of microorganisms inhabiting the oral cavity; color change; the appearance of pa…
Introduction. The identification of molecular components contributes to the realization of the targeted properties of multicomponent drugs to study their molecular mechanism and therapeutic targets. The polypeptide complex isolated from cattle thymus (thymalin…
Due to the discovery of the proprotein convertase subtilisin/kexin type 9 (PCSK9) and the establishment of its role in lipoprotein metabolism, it became possible to deliver new groups of effective drugs for the treatment of dyslipidemia. The main function of P…
Introduction. The main attention of researchers is paid to the study of one of the members of the EGF family – the receptor of epidermal growth factor 2 (Her2/neu), the overexpression of which is detected in 15–20% of cases of invasive breast cancer and had an…
Introduction. The formation of neurofibrillary plexuses and the accumulation of senile plaques in the parenchyma and cerebral vessels are the key pathological signs of Alzheimer’s disease presenting a neurodegenerative disease. The main component of senile pla…
The neurotrophic hypothesis of depressive disorders has gained widespread recognition nowadays. This review is devoted to the brain-derived neurotrophic factor (BDNF) system in the pathogenesis of depression and major depressive disorder. We describe the struc…
Introduction. Degenerative retinal diseases are considered as the leading cause of blindness and low vision worldwide. The last studies have provided convincing evidence of the involvement of immunological factors in the development and progression of the dise…
Little is known about the etiology of neuropsychiatric disorders. Glutamate-mediated excitotoxicity is one of the main pathological mechanisms occurring in various types of acute and chronic diseases of the central nervous system. Glutamate is the major excita…
Introduction. In recent years, alternative framework proteins are used for the targeted radionuclide imaging. Molecules of DARPin (Design Ankyrin Repeat Protein) are one of the representatives of scaffolds. Despite the continued increase in the number of molec…
Introduction. Timely diagnosis and a personalized approach to the treatment of diseases is accepted to be one of the most important modern tasks in medicine and in particular, dentistry. The use of pharmaceuticals for the diagnosis and treatment of various dis…
Introduction. Molecular genetic research methods suggest the development of certain forms of pancreatitis and its complications. Aim of the study. Identification of risk factors for the development of acute forms of pancreatitis based on molecular genetic stud…
Introduction. Human platelets maintain big reparative and regenerative potential. The biochemical content of platelet preparations seriously depends on methodic features. The aim of the study. To study cytokine content in different types of platelet soluble pr…
Lung cancer occupies the leading position in at the structure of oncological morbidity in the developed countries. The overall five-year survival rate for lung cancer isn’t exceed to 10–20% even using of the entire modern arsenal of therapeutic methods. Multip…