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Molecular Medicine
Found: 348
Review is devoted to systems for drug delivery of biologically active substances in the tissues and organs of the target cells, which is relevant to medicine. There are described properties of mesenchymal stromal cells (MSCs), which many authors propose to use…
MicroRNAs (miRNAs) – small non-coding RNAs targeting multiple mRNAs – are posttranscriptional regulators of gene expression involved in carcinogenesis, metastasis, and invasion. MiRNAs expression is altered in various human tumors including ovarian cancer. Ana…
Introduction. Glaucoma is associated with a progressive decrease of visual functions, leading to blindness. One of the important factors is the outflow of the ocular fluid. А genetic association study has identified a sequence variant at the chromosome 7q31 (r…
Introduction. Oxidative stress is developed as a result of imbalance between the generation of reactive oxygen species and activity of the antioxidant defence system. This in turn results in profound changes in metabolism of lipids, proteins and nucleic acids,…
The aim of the study. The proof of afobazole efficacy for treatment and prevention of alcoholic cardiomyopathy and attendant complications using the previously developed translational model. Materials and methods. Alcoholic cardiomyopathy was produced by conti…
Introduction. Age-assosiated endothelial changes are one of the reasons of the development of cardio-vascular pathology. Moreover, molecular mechanisms of human endothelium aging are investigated only slightly. Thus, the problem of pathogenesis of cardio-vascu…
Introduction. Mutations in the tumor suppressor gene TP53 are observed approximately in the half of all human malignancies. In bladder cancer (BC), ТР53 molecular alterations were shown to be associated with more aggressive tumor phenotype; however their clini…
Introduction. Producing of combined biotransplants with human platelets may be accompanied by high rate of the loss of biological active platelet components. It is suggested to use blockers of platelet activity to fix these cells on adhesive substrate surface.…
Introduction. Chemokines are a group of proteins that plays an active role in the regulation of the vascular wall inflammation during the development of essential hypertension. The aim of the study was to investigate an association between essential hypertensi…
Introduction: Insulin-like growth factors (IGFs), insulin-like growth factor-I receptor (IGF-IR), IGR-binding proteins (IGFBPs) and IGBP proteases can play an important role in the development of metastases in ovarian cancer. The relationship between IGF syste…
Introduction. Targeted gene delivery plays an exceptional role in the development of gene therapy. Peptide-based carriers are promising group of non-viral gene delivery vehicles due to biodegradability and easy structural and amino acid sequence modifications.…
Introduction. Owing to the intensive development of neurosciences immunoassay methods have received a widespread use. These methods allow studying the functioning features of the nervous system in trauma at the molecular level . The purpose of the study. The p…
Introduction. KRAS mutations play a critical role in human tumorigenesis and are the most prevalent in colorectal cancer. Because KRAS is the most frequently mutated factor downstream of the EGFR signaling pathway, it was considered to be a candidate molecular…
Introduction. The phenomenon of drug resistance of Mycobacterium tuberculosis complex is extremely complicated. The determination of the genetic changes is not always able to explain reasons of this effect clearly. The aim of the study. Molecular genetic analy…
Introduction. Biomimetic peptides – are synthetic compounds which are identical to amino acid sequence that are synthesized by organizm, which can interact with growth factor receptors and provide antiaging clinical effect. The aim of the study. Investigation …
Introduction. Atherosclerosis proves to be age-dependent and social significant pathology. Knowledge of the role of signaling molecules in its development, and the elaboration on this basis molecular markers of restenosis after stenting of arteries remains to …
Introduction. The elevated expression of components of DNA repair system ERCC1 (excision repair cross-complementing group 1) and XPD (Xeroderma pigmentosum group D) is associated with the lack of efficacy of DNA–damaging cytotoxic platinum-based preparations. …
Introduction. Amnesic shellfish poisoning is caused by consumption of seafoods contaminated with domoic acid (DA) and is accompanied by gastric colics, nausea, convulsions, hallucinations, loss of orientation and amnesia. As a preventive measure against these …
There is represented immunohistochemical and molecular biological characteristic of some histological types of breast cancer. The assessment of molecular biomarkers in breast cancer has two practical results: identification of risk groups, requiring additional…
The key role in the achievement of the main goals of personalized medicine in oncology i.e. treatment choice according to patient’s individual characteristics and biological properties of the tumor belongs to tumor molecular markers characterizing the specific…