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Molecular Medicine
Found: 848
Introduction. Developing of chronic emotional stress reduces adaptive capabilities of people ill with diabetes mellitus causing the condition of decompensation with significant elevation of counterinsular hormones production and further progressive metabolic d…
Introduction. The human microbiota is part of the «human-microbiome» system and is actively involved in developing various pathological responses and conditions in the body. It is currently essential to study the pathogenesis of ulcerative colitis (UC), a poly…
The aim was to correlate the content of cytokines/chemokines in the oral fluid of patients undergoing orthodontic treatment with the results of laser correlation (LC) spectroscopy in order to develop approaches to prenosological diagnostics. Methods. Oropharyn…
Introduction. Under the influence of glioma cells, peritumoral zone astrocytes may acquire tumorigenic phenotype, particularly due to the suppression of immunocompetent cells. The aim of the study. Investigate the changes in the gene expression profile of glio…
Introduction. The study of the mechanisms of multicellular system regulation and of complex balance between two basic physiologic processes, proliferation and apoptosis, is actual task of the modern molecular biology and medicine. Purpose of the study – the in…
Introduction. Single nucleotide polymorphisms rs34643859 of the KCNS1 gene, rs12804550 of the SCN4B gene, and rs4514993 of the SCN11A gene were revealed in the analysis of the results of whole exome sequencing of a group of young man died by sudden cardiac dea…
Introduction: Urate nephrolithiasis is a common form of urolithiasis. The development of new methods for pharmacological correction of this disorder requires their practical laboratory assessment. So far, it is necessary to determine the most typical biochemic…
Introduction. Advances in biology and medicine in particular in the field of cell technologies allow us to test eye stem cells as an alternative to surgical treatment of corneal pathology. An option to increase the resistance of stem cells to adverse microenvi…
Background: The aim of this study was to investigate individual changes of protein expression in atherosclerotic plaques of coronary arteries at different stages of development of coronary atherosclerosis. Methods: The research object was homogenates of athero…
Recently, the involvement of histamine in the regulation of the function of cells in the immune system has been actively studied, including the ability of the mediator to modulate inflammatory responses of different cell types to infectious agents by activatin…
Introduction. The therapeutic effect of orotic acid (OA) is limited by the low absorption of the drug from the gАСТrointestinal tract, which can be overcome when the drug is processed by mechanical activation. The aim of the study is a comparative experimental…
Introduction. Urological and genital malignant neoplasms in men are an urgent problem. Every year, about 403.3 thousand newly diagnosed cases of kidney cancer and 34.5 thousand of penile cancer are registered in the world. With metabolic atypism, a change in a…
Sarcopenia is a progressive and generalized pathology of skeletal muscles of multi-factor nature. The present review focuses on the analysis of molecular genetic markers that may contribute both to sarcopenia risk formation and the variability of diagnosticall…
The review presents literature data that reveal the mechanism of mutual influence of microbiota and melatonin in the unified system «mother–placenta–fetus». There is shown the variety of functions performed by the microbiota, provided by the presence of commun…
Introduction. Atopic dermatitis is a chronic inflammatory disease caused by a complex interaction of genetic, immune, and environmental factors. Recently, the study of epigenetic changes has brought new insights into the etiology of atopic dermatitis. Aim of t…
Introduction: nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. But it remains unclear what factors influence the progression of the disease. It is interesting to study the influence of the genetic aspect on the course of NAF…
Introduction. The cytostatics, inhibiting the cellular proliferation, are using in clinic for the inhibition of tumor development in patients. However, the adverse events can occur because of the damage of health cells of other tissues. A delay or decrease of …
Osteopontin (OPN) is a highly phosphorylated multifunctional glycosphoprotein with important functional activity in cancer and cardiovascular diseases, diabetes mellitus (DM), kidney and liver pathology, inflammatory process, and also influencing cell viabilit…
Introduction. Aging is associated with a decrease in the neuro- and synaptogenesis as well as hyperactivation of glial cells, which leads to changes in the morphofunctional state of the nervous tissue of the hippocampus and, as a consequence, a deterioration i…
Introduction. The oral cavity is the beginning of the human digestive system and the presence of pathological changes in it: a shift in the dynamic balance, composition, and types of microorganisms inhabiting the oral cavity; color change; the appearance of pa…