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Molecular Medicine
Found: 690
Aim. The work was carried out to study the role and features of small intestine bacterial overgrowth (SIBO) in the pathogenesis of bronchial asthma (BA). Material and methods. 80 BA patients were included in the study. SIBO was detected by the hydrogen breath …
Objective: a morphological study of the transcription factors NeuroD1, Nkx2.2, Isl1; somatostatin and chromogranin A in various forms of CH The methods included immunohistochemistry examination with antibodies to NeuroD1, insulin, somatostatin, ChrA, Nkx2.2, I…
Introduction. Ovarian clear cell carcinoma (OCCC) is a subtype of epithelial ovarian cancer characterized by frequent mutations in the ARID1A gene and low sensitivity to standard-of-care chemotherapeutic agents. The aim of the study. To determine the role of A…
The review summarizes a number of published reports about the influence of total hormonal and metabolic disturbances on the functioning system mother – placenta – fetus in the organism of the women with obesity and gestational diabetes mellitus. The circadian …
Introduction. In the treatment of non-alcoholic fatty liver disease (NAFLD), which is the main cause of chronic liver disease, a certain role is assigned to hepatoprotectors. One of the hepatoprotectors currently used to treat NAFLD is ademetionine. At the sam…
Introduction. Sarcoidosis is a systemic granulomatous disease of unknown etiology, which leads to disruption of the human respiratory system and can lead to damage to other systems. In clinical practice, doctors often run into difficulties in differentiating s…
Introduction. The molecular mechanisms of the development of tumor pathology of the thyroid gland are associated with the activation of angiogenesis and the development of hypoxia, which contributes to the proliferation, invasion, and progression of the diseas…
The review considers the role of hyaluronic acid (HA), primarily low-molecular-weight fractions of HA, in the regulation of the cell cycle of tumor cells. The formation of a pool of low-molecular weight HA molecules is due to the high activity of hyaluronidase…
Introduction. The main function of alpha-1 antitrypsin (A1AT) is inhibition of neutrophil elastinase and control over TNFα secretion. Anti-inflammatory properties of A1AT are manifested in leucocyte migration decrease and proliferation of T-lymphocytes through…
Introduction. The decline in collagen I type synthesis and the gain in matrix metalloproteinases (MMPs) activity are the main characteristics of the molecular skin aging. MMPs are ferments which cleave collagen. The aim of the study was to investigate the infl…
Introduction. The specific activity of blood coagulation factor VIIa depends, among other things, on the presence of N-acetylneuraminic acid (sialic acid) and phosphate residues in the molecule. Thus the authenticity of glycosylation profile as one efficacy an…
The purpose of this review is a systematic analysis of data from clinical observations, international experience, and reviews related to the pathogenetic aspects of the impact of a new coronavirus infection on the blood system. Information was searched in MedL…
Introduction. The development of neurodegeneration in Alzheimer’s disease is inextricably linked with oxidative stress, a marker of which is oxidative protein modification. In the tissues of the brain, cerebrospinal fluid and plasma in Alzheimer’s disease, an …
Introduction. The single-nucleotide polymorphisms rs75555045 and rs12904699 were found in the own genome-wide allelotyping as possible new molecular genetic markers of sudden cardiac death (SCD). The results obtained in such studies require verification in the…
Communities of microorganisms are a set of species that interact with each other and occupy the same niche where competitive or mutually beneficial relationships can occur. Biofilms are only one of many types of microbial communities, the study of which has be…
Introduction. Based on current literature data, it is possible to assume that when exposed to glioma cells astrocytes, may undergo a reactive transformation. These glioma-conditioned astrocytes might create a permissive environment for tumorigenesis. The aim o…
Introduction. Hyaluronic acid in combination with other biology active molecules and ions is an efficient drug for the function restoration and normalizing an external appearance of the skin during aging. However, the comparative investigation of hyaluronic ac…
Introduction. To assess the pharmacokinetic indices of new drugs, it is necessary to develop analytical methods for determining their concentration in biological objects. Purpose of the study. Development and validation of HPLC-mass spectrometric methods for t…
Introduction. The pathological state of hypoxia of the body occurs with an inadequate supply of tissues and organs with oxygen or with a violation of its utilization in the process of biological oxidation. Ethylmethylhydroxypyridine has a multi-component mecha…
Progress in clinical research and medicine has contributed to a significant reduction in the worldwide mortality rate. Currently, the strategy of developed countries is directed at increasing expectancy and improving life quality. As a consequence, the modern …