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Molecular Medicine
Found: 433
Introduction. Uterine fibroids – a benign tumor, growing from immature muscle cells of the vascular wall of the uterus. It ranked first among the benign tumors of the genital organs, with one in ten suffers from gynecological patients with uterine myoma. The a…
Introduction. Determination of the role of genetic markers in the formation of individual susceptibility to the effects of harmful chemicals both opens up new possibilities for assessing the risk of occupational and production-related diseases and address prev…
Introduction. Diabetes mellitus type 1 and type 2 are having a number similar etiological factors and certain resemblance in the mechanisms of the disease. Therefore it is important to try to estimate the role of common genetic component in the genesis and for…
Renal cancer is among the most common oncourological diseases, and represents a heterogeneous group of tumors, which up to 80% is a clear cell renal cancer (CCRC). The study of rare hereditary forms of CCRC led to identification of the VHL gene; germinal VHL m…
Staphylococcus aureus – the pathogenic microorganism that can cause as well hospital as community-acquired diseases. The emergence and subsequent spread of strains resistant to many antimicrobial agents, and, above all, methicillin-hospital strains (HA-MRSA) a…
Introduction. The pathogenesis of inflammatory bowel disease is complex and multifactorial. Studies have led to the current concept that the T-helper cells are components of the adaptive immune response whereas Toll-like receptors, NOD-like-receptors, RIG-I-li…
Introduction. In IVF-cycles ≈70% of human oocytes have different morphological abnormalities (dysmorphisms). Embryos from dysmorhic oocytes may have delay in development due to mitochondrial dysfunction and disorders of energy accumulation in the cell. The aim…
Introduction. Diploid human fibroblasts lines (DHFL) are widely used in diagnostic virology and experimental studies. One of the directions of use DHFL in virology and immunology is to create on their basis of a test system for determining the activity of inte…
Introduction. Clinical observations have revealed that the treatment of schizophrenia with the use of chlorpromazine (CPZ) impairs cognitive processes. Whether it is possible to eliminate these side effects of CPZ? The aim of the study. The aim of our study wa…
Introduction. Oxidative processes in the pathogenesis of chronic cardiovascular diseases play a key role. Oxidative stress causes the damage of many cellular components, including lipids and proteins. Oxidative modification of low-density lipoprotein triggers …
Introduction. The ACTA2 gene encodes α-actin in aortic smooth muscle cells, and its mutations may cause thoracic aortic aneurysms. Analysis of ACTA2 polymorphism can be used in a complex risk assessment of non-familial thoracic aortic aneurysms. The aim of the…
The purpose of the study was to analyze publications on circulating tumor cells and to conduct our own research. Detection of circulating tumor cells was made in 60 patients with colorectal cancer and resectable metastatic liver lesion Т2-4N0-1M1 on the tenth …
Introduction. Currently there was described a number of subpopulations of haematopoietic stem cells and progenitor cells, important for completeness of the recovery of hematopoiesis and antigens involved in the process of homing, adhesion and mobilization of h…
Introduction. Mediator release from mast cells or basophils is the key event in many acute allergic and inflammatory processes. Rat basophilic leukemia cell line RBL-2H3 cells is widely used as a model for studying mast cells degranulation. Aim of the study. T…
Introduction. Study of growth factors content in tumors of different localizations and assessment of their probable correlation with the main clinical and morphological characteristics are relevant nowadays. Products of expression of the viral genome – E7 and …
Introduction. Immunologic microenvironment of malignant tumors is likely to be significant in «tumor-host» interaction. The aim of the study. Сomparative analysis of systemic and local factors of cellular and humoral immunity in patients with ascitic forms of …
The literature review provides information on the molecular biology of low-grade malignancy gliomas (LGMG) in children and adolescents. The data on specific genetic aberrations in pilocytic astrocytoma, pleomorphic xantoastrocytoma, subependimal giant cell ast…
The problem of the treatment of hyperplastic diseases of endometrium currently remains to be a matter of interest. Existing methods of hormone therapy fail to differ in high efficacy. Authors tried to find out reasons for the lack of success of hormonal manage…
Introduction. Binding of the human immunodeficiency virus (HIV) envelope gp120 glycoprotein to CD4 and CCR5 receptors on the cell membrane initiates the viral entry process. Simultaneous expression of these two receptors has been observed on T-lymphocytes, mon…
Introduction. Short-term and long-term memory impairments are the main symptoms of several socially important neurodegenerative disorders, such as Alzheimer disease. For this purpose the pharmacological enhancement of short-term memory is of great interest. No…