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Molecular Medicine
Found: 559
Introduction. Atherosclerosis, manifesting itself as acute coronary syndrome, stroke, and peripheral artery disease, is a chronic progressive inflammatory disease driven by both innate and adaptive immunity. As Triggering Receptor Expressed on Myeloid Cells-1 …
Introduction. Alzheimer's disease (AD) is a socially important neurodegenerative disease. The prevalence rate of AD is increasing over recent years. According to the hypothesis concerning AD to be a systematic disease its manifestation can be detected in vario…
The frequency of reported cases of melanoma and related mortality rates continue to increase worldwide. The study of the basic mechanisms of both the initiation and development of this highly aggressive tumour proves to be important for the identification of t…
The review deals with the analysis of experimental results relating to the protective effect of mesenchymal stem cells (MSCs) after the brain damage. We consider two mechanisms of the MSCs action. The first proposed mechanism is associated with the ability of …
Telomerase catalytic subunit hTERT is tightly regulated both at the transcriptional and posttranscriptional levels. One of the regulatory mechanisms is its mRNA alternative splicing. Only full-length form has catalytic activity and the ability to elongate telo…
Introduction. Hypermethylation of CpG islands in tumor-suppressor genes are supposed to be a key mechanism of the development of the myelodysplastic syndrome (MDS) The aim of the study. To determine the association between methylation status of SOX7, p15INK4b,…
Exosomes are microscopic extracellular vesicles with diametr 30–100 nm, which are secreted by different types of cells and may be detected in normal (blood serum, saliva, urine, breast milk) and pathological (ascite) biological fluids. It was shown that exosom…
The role of key adipokines (leptin, adiponectin, resistin, visfatin, apelin, omentin) had been assessed as important factors for perinatal complications in mother with disorders of carbohydrate metabolism. The survey based on the analysis of literature data. H…
A half century of studying the neurogenesis of the adult brain has produced much evidence for an endogenous conversion of neural stem cells. Yet the idea receives increasing criticism, in addition to the many positive comments. Does neurogenesis proceed at a r…
Introduction. The project mimicked the conditions of a manned Mars mission during which six volunteers stayed in a closed complex for 520 days. The aim of the study. The main goal of the research was the complex assessment of blood samples of volunteers for th…
Introduction. Penicillins and macrolides are applied for the treatment of both diphtheria carriers, in the comprehensive therapy of separate forms of diphtheria, and patients with invasive diseases caused by nontoxigenic C. diphtheriae. In the 1990s there was …
Introduction. Contracting deep scars are almost unresponsive to conservative treatment and often require repeated surgical intervention. These scars represent a serious problem in skin therapy after the extensive damage. Just the impairment of processes of the…
Aim is to evaluate distribution and clinical significance of gene CYP2C19 polymorfism in ST-segment elevation myocardial infarction (STEMI) patients. Materials and methods. A total of 159 patients were encluded in this study. All of them underwent primary PCI.…
Preeclampsia is the pregnancy complication characterized by the presence of arterial hypertension and proteinuria. Preeclampsia is the leading cause of maternal and perinatal morbidity and mortality. To date, there are more than 40 advanced theories of etiopat…
Introduction. Osteoartitis (OA) is the polyetiological disease pathogenesis of which is not fully understood. One of the risk factors for osteoarthritis may be connective tissue dysplasia, which is based on genetic defects of cartilage structures. The aim is t…
Introduction. EGFR mutation and EML4-ALK fusion are the most clinically significant genetic alterations in non-small cell lung cancer. Numerous studies have been devoted to EGFR mutations and their association with phenotypic clinical and pathological characte…
The use of haloperidol in clinical practice is often accompanied by the development of severe unwanted adverse side effects from the side of various organs and systems. In the narcological practice the use of antipsychotic drugs is not seldom complicated by ex…
In this brief review there are considered possible reasons for the spread of disease of the multifactorial nature in modern populations from standpoints of the discordance between evolutionary formed genetic diversity and rapidly changing environmental factors…
Alzheimer's disease being the socially significant neurodegenerative disease of the elderly, ranks 6th on the causes of death among somatic pathologies. The molecular mechanisms of Alzheimer's disease still remain unexplored until the end, and the efficacy of …
The aim of this work was to study the relationship between adiponectin gene polymorphisms G276T with obesity and obesity-related diseases in the Kyrgyz population. Material and methods. We genotyped 288 Kyrgyz subjects (143 women and 145 men; age range: 30–75 …