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Molecular Medicine
Found: 338
Introduction. The study of mechanisms of multicellular system regulation and of cellular proliferation balanced status in the organism tissues is one of the actual task of modern biology and medicine. Purpose of study. Effect of encoded amino acids combination…
Introduction. Studies consider the immune and neuroendocrine systems as actively interacting with each other and priority participating in the complex maintenance of homeostasis. Immune processes are dependent on the functional activity of the endocrine system…
Introduction. Oxidative stress (OS) occurs in various pathological processes, and acting as a nonspecific link in their pathogenesis. Less is known about its physiological role. The aim of study. Analysis of the results of world literature data and our own res…
Introduction. Despite numerous studies in the field of neurodegenerative diseases, the exact mechanisms of these processes have not yet been identified. The purpose of this review is to analyze the methodological approaches necessary to revise the traditional …
Introduction. Sequencing of single cells makes it possible to characterize the cellular and molecular composition of tissues, the state of DNA, RNA and expressed proteins. The «single-cell» sequencing method is gaining increasing popularity in modern biology a…
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality. An important task in cardiology is the search and study of new biomarkers. Scientific interest is actively focused on the study of interleukin-11 (IL-11). The purpose of the literature…
Introduction. An increasing number of reports of long-term negative consequences of COVID-19, characterized by chronic inflammation, tissue hypoxia, oxidative stress, metabolic changes at the level of all body systems, determines the search for criteria for as…
Introduction. It is known that in the pathogenesis of caries and non-carious lesions of teeth, an important role is played by enamel resistance, which is determined by numerous factors, among which the structure and physical and mechanical properties of tooth …
Introduction. DNMT3A is one of the most frequently mutated genes in acute myeloid leukemia (AML), and the R882H (G>A) substitution is one of the most common mutations in this gene. Restriction analysis and high resolution melting (HRM) analysis are the most co…
Introduction. Recurrent pregnancy loss (RPL) is an early spontaneous termination of pregnancy before 20 weeks, which is defined as two or more miscarriages. Most of the known causes associated with the pathophysiology of RPL include endocrine disorders, antiph…
Introduction. An urgent problem in biology and medicine is the identification of biologically active molecules that affect the cellular processes of proliferation and apoptosis in various tissues of the body. Purpose of the study. The purpose of this study was…
Introduction. The use of mesenchymal stem cells (MSCs) is recognized as a promising direction for the treatment of diseases with a predominance of inflammation and sclerosis in the pathogenesis, which includes nephrotuberculosis (NT). Target. Studying the effe…
Relevance. The review is devoted to the analysis of modern ideas about the functional role of connexins in intercellular interactions, their participation in maintaining cellular and tissue homeostasis and in the pathogenesis of diseases of the respiratory sys…
Introduction. There is a steady increase in the incidence of type 2 diabetes worldwide. One of the most formidable complications of this pathology is the development of diabetic foot syndrome, which is accompanied by up to 50% of cases of high amputations, dis…
Introduction. Trace elements are widely involved in various metabolic processes in humans, including thyroid hormones. Iodine is a part of thyroid hormones, is actively involved in the work of thyroid enzymes, copper, zinc and manganese are included in the com…
Introduction. Cervical cancer is one of the most common cancers of the female reproductive system, killing more than 250,000 women each year. The etiological agent that causes cervical cancer is well known. HPV infection with high oncogenic risk is the cause o…
Introduction. The effectiveness of antitumor immunity is determined by various mechanisms of recognition of tumor antigens, while the diversity of the repertoire of antigenic receptors is determined by V(D)J recombinations in maturing T and B cells. The aim of…
This review is devoted to summarizing the available data on the expression of long non-coding RNAs (lncRNAs) in lung cancer cells and tissues, their role in tumorigenesis, association with clinical and morphological characteristics and disease prognosis. The p…
Introduction. The search for molecular markers of adverse treatment outcomes in individuals with pulmonary tuberculosis (PT) is relevant due to the worldwide increase in drug resistance of Mycobacterium tuberculosis (MBT) strains to anti-tuberculosis drugs (PT…
Cortical dyslamination with neuronal dysmorphism that occurs adjacent to an arteriovenous malformation (AVM) and is accompanied by epilepsy (E) is classified as FCD IIIc. Its etiology and pathogenesis have yet to be determined. Objective: to clarify the cellul…