Found: 66
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2020
Solomina A.S., Shreder O.V., Mokrova E.D., Zabrodina V.V., Gorbatova D.M., Kolik L.G, Durnev A.D.
Introduction. Influence of environmental hazards on pregnant women or development of pregnancy in presence of pathogenic pathway may lead to miscarriage, teratogenic effects and/or significant abnormalities in physical development, cognitive and behavioral sta…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2020
Ershov P.V., Kaluzhskiy L.A, Ivanov A.S.
Introduction. The quantitative determination and isotyping of autoantibodies to a clinically significant protein – glutathione-S-transferase (GST) in blood serum samples is relevant for monitoring and predicting the dynamics of autoimmune processes. The aim of…
ОБЗОР2019
Chernysheva M.P., Nozdrachev A.D.
Peptidergic structures of the hypothalamus arrange a basis of its unique ability to regulate the organism's functions in time, adjusting metabolism, energy exchange and motor activity as sources of its own energy- to the dynamics of energy intake from external…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2019
Selifonov A.A., Naumova G.N., Tuchin V.V.
Introduction. Dyes have long been successfully used in medicine as exogenous chromophores to increase the effectiveness of the interaction of light with biological tissues, as contrast agents and photosensitizers in diagnosis and photodynamic therapy. At prese…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2019
Isakova Zh.T., Kipen V.N., Talaibekova E.T., Aldashev A.A., Aldasheva N.M., Bectursunov T.M., Mirrakhimov E.M.
Aim. To study the intergenic interaction and estimate the contribution of polymorphic loci p.K23E (rs5219, KCNJ11), g.15661G>T (rs1501299, ADIPOQ), p.V109D (rs2274907, ITLN1), g.2453G>A (rs7799039, LEP), g.53341C>T (rs7903146, TCF7L2), and p.P12A (rs1801282, P…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2019
Bystrova E.Yu., Platonova O.N., Shpanskaya A.A., Dvornikova K.A., Nozdrachev A.D.
Introduction. At present, signaling pathways involved in the development of innate and adaptive immune responses and comprising, inter alia, the interaction of pattern-recognizing receptors, such as TLR, with antimicrobial peptides associated with inflammation…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2018
Milyakova M.N., Ponomareva J.V., Laykov A.V., Limareva L.V.
Introduction. Interaction of prosthetic devices with surrounding tissues is based on protein absorption. Protein adsorption is the first stage of the interaction between prosthetic materials with tissues in the body. The number, composition, conformation chang…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2018
Kvetnoy КI.M., Kleimenova T.S., Rodichkina V.R., Drobintseva A.O., Polyakova V.O., Tsypurdeeva A.A., Orazov M.R., Polikarpova S.R.
Introduction. The article is devoted to the actual medical and social problem of modern reproductive medicine – new approaches to improve and regenerate the implantation susceptibility of the endometrium in infertility. Currently, in addition to traditional ho…
ОБЗОР2018
Kondratyev A.V., Shnayder N.A., Shulmin A.V., Lomakin A.I.
The headache is an important medical and social problem. Currently, genetics is the least-studied component of the pathogenesis of primary headaches. The most common forms of primary headache include migraine, tension type headache, cluster headache. This arti…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Panteleyev A.A., Usakin L.A., Tverye E.A., Chikitkina Yu.A., Rudayk S.G., Paltsev M.A.
Introduction. The physiological state of the skin vasculature is largely determined by the influence of environmental factors, including the alteration of the oxygen partial pressure. Obviously, the epidermis, as the surface layer of the skin, should play a ke…
ОБЗОР2017
Makarov M.S.
The review presents data concerning the interaction of basic types of nanoparticles with human platelets in vitro and in vivo and biological results of this influence. The initial structure of nanoparticles and their biologically active cargo can both stimulat…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016
Kucher A.N., Tarasenko N.V., Puzyrev V.P.
Introduction. Diabetes mellitus type 1 and type 2 are having a number similar etiological factors and certain resemblance in the mechanisms of the disease. Therefore it is important to try to estimate the role of common genetic component in the genesis and for…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016
Zlatnik E.Yu., Nerodo G.A., Novikova I.A., Bakhtin A.V., Zakora G.I., Selyutina O.N., Ardzha A.Yu.
Introduction. Immunologic microenvironment of malignant tumors is likely to be significant in «tumor-host» interaction. The aim of the study. Сomparative analysis of systemic and local factors of cellular and humoral immunity in patients with ascitic forms of …
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015
Yunusova N.V., Kondakova I.V., Kolomiets L.A., Villert A.B.
Introduction: Insulin-like growth factors (IGFs), insulin-like growth factor-I receptor (IGF-IR), IGR-binding proteins (IGFBPs) and IGBP proteases can play an important role in the development of metastases in ovarian cancer. The relationship between IGF syste…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015
Ludannyy R.I., Alvarez Figueroa M.V., Prokopenko A.V., Valdokhina A.V., Shipulin G.A.
Introduction. The phenomenon of drug resistance of Mycobacterium tuberculosis complex is extremely complicated. The determination of the genetic changes is not always able to explain reasons of this effect clearly. The aim of the study. Molecular genetic analy…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015
Paltsev M.A., Soldatov V.M., Kozlov K.L., Paltseva E.M., Linkova N.S., Polyakova V.O., Sedova E.V., Mursalov S.U., Kvetnoy I.M.
Introduction. Atherosclerosis proves to be age-dependent and social significant pathology. Knowledge of the role of signaling molecules in its development, and the elaboration on this basis molecular markers of restenosis after stenting of arteries remains to …
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015
Alexeev А.А., Brylev M.I., Korolev V.L., Lotorev D.S., Lizunov A.Yu., Zaitseva N.I., Pavlova L.А., Ivshin V.P.
Introduction. Cardiovascular diseases consistently occupy the first place among causes of death and disability in almost all developed countries. The main importance of this group of diseases have myocardial infarction. One of the causes of myocardial infarcti…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015
Nazarenko G.I., Zhuravlev Yu.I., Ryazanov V.V., Konstantinova M.V., Kleymenova E.B.
Introduction. Ischemic stroke (IS) is a multifactorial disease, resulting from a complex interaction of genetic and environmental factors. Individual cause of the disease, multiple factors and symptoms require advanced mathematical methods of predicting IS ris…
ОБЗОР2015
Matosyan K.A., Pustovalov D.A., Oranskaya A.N., Mkrtumyan A.M., Gurevich K.G.
Since the middle of the last century, discoveries in the area of molecular biology and physiology somehow led to the revolution in the view of the function and role of the adipocyte in the human body. To date, there have been known and studied more than four a…
Research article2014
Urazova O.I., Khasanova R.R., Esimova I.E., Novitsky V.V., Churina E.G., Kononova T.E.
Introduction. Disorders in anti-TB immunity may be formed at the stage of interaction between antigen-presenting cells and T-lymphocytes by means of cytokines and their receptors. The key cytokines of T-lymphocyte activation are interleukins (IL) of the IL12 f…