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Molecular Medicine
Found: 69
Introduction. The most common invasive malignant tumor of uterine is endometrial cancer. In process of tissues malignancy the critical role belongs to changes in signaling pathways which regulate apoptosis. The aim of study was to analyze changes in the expres…
The aim of the study. This study was designed to explore relationships between the activation of signaling pathways triggered by a novel cardioprotective drug Metilin, on one hand, and the recovery of metabolic state and the membrane stability in cardiomyocyte…
Introduction. Papillary thyroid cancer (PTC) is the most common malignancy of the endocrine system. As the most frequent genetic alteration BRAF V600E mutation in PTC leads to changes in the activity of intracellular signaling pathways. As a result, expression…
Introduction. The physiological state of the skin vasculature is largely determined by the influence of environmental factors, including the alteration of the oxygen partial pressure. Obviously, the epidermis, as the surface layer of the skin, should play a ke…
The data concerning the changes of expression and posttranslational modification of the human protein under the influence of the external and internal irradiation in vivo and in vitro are presented in this review. The investigation of protein expression and po…
Uveal melanoma (UM) is a rare, aggressive intraocular malignant tumor, leading to metastatic disease in more than 50% of patients. Cytogenetic and molecular studies have identified some genetic prognostic factors considered to be reliable to forecast the survi…
Introduction authors made an attempt to demonstrate the role of DNA-methylation in pathogenesis of uterine fibroids. The epigenetic aspects based on personal investigations and literary data have been reviewed. The research underlined a perspective of investig…
Introduction. Hepatitis C virus (HCV) is a major risk factor for chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Molecular mechanisms of fibrogenesis are associated with the activation or inhibition of signaling pathways, which are controlling…
The frequency of reported cases of melanoma and related mortality rates continue to increase worldwide. The study of the basic mechanisms of both the initiation and development of this highly aggressive tumour proves to be important for the identification of t…
In the presented review a new potential risk factor for atherosclerosis and cardiovascular disease such as microflora of the human gastrointestinal tract is considered. The modern concept of lipid metabolism and its effects on human health outlining the basic …
Introduction. Hypermethylation of CpG islands in tumor-suppressor genes are supposed to be a key mechanism of the development of the myelodysplastic syndrome (MDS) The aim of the study. To determine the association between methylation status of SOX7, p15INK4b,…
Energy supply of cells can be provided through both an oxygen-dependent pathway of mitochondrial oxidative phosphorylation and oxygenindependent glycolysis. Oxidative phosphorylation in the synthesis of ATP is more efficient than in glycolysis, and respectivel…
Introduction. The transcriptional activity of hypoxia-inducible factor 1 (HIF1) not only drives cellular adaptation to O2 deficiency, but also plays an important role in the development and functioning of various organs and tissues. Data on the role of HIF reg…
Introduction. Diabetes mellitus type 1 and type 2 are having a number similar etiological factors and certain resemblance in the mechanisms of the disease. Therefore it is important to try to estimate the role of common genetic component in the genesis and for…
Renal cancer is among the most common oncourological diseases, and represents a heterogeneous group of tumors, which up to 80% is a clear cell renal cancer (CCRC). The study of rare hereditary forms of CCRC led to identification of the VHL gene; germinal VHL m…
Introduction. Gastric cancer is a global problem for the health systems worldwide. Today it takes the fourth place in the world in the morbidity and the second place in the mortality structure. In Russian Federation, almost 70% of gastric cancer cases are diag…
Introduction. Study of growth factors content in tumors of different localizations and assessment of their probable correlation with the main clinical and morphological characteristics are relevant nowadays. Products of expression of the viral genome – E7 and …
Introduction. KRAS mutations play a critical role in human tumorigenesis and are the most prevalent in colorectal cancer. Because KRAS is the most frequently mutated factor downstream of the EGFR signaling pathway, it was considered to be a candidate molecular…
Hepatocellular carcinoma (HCC) is the most prevalent form of malignant liver cancer characterized by late detection time and highly aggressiveness. The main risk factors for HCC development are chronic infections of hepatitis B and C viruses, cirrhosis, liver …
Introduction. Activation of eNOS/sGC/cGMP-pathway is a common link in the development of angiogenic action of the majority of pro-angiogenic factors. In this regard, the chemical inhibition of NOS (Nitric Oxide Synthase) may cause a nonspecific angiostatic eff…