Found: 98
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2020
Solomina A.S., Shreder O.V., Mokrova E.D., Zabrodina V.V., Gorbatova D.M., Kolik L.G, Durnev A.D.
Introduction. Influence of environmental hazards on pregnant women or development of pregnancy in presence of pathogenic pathway may lead to miscarriage, teratogenic effects and/or significant abnormalities in physical development, cognitive and behavioral sta…
ОБЗОР2020
Borodulina E.A., Yakovleva E.V.
Iron is an essential trace element not only for the human body, but also for some microorganisms, including mycobacterium tuberculosis. Being strict aerobes, mycobacteria receive iron from the human body using the siderophore transporter system. Iron deficienc…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2019
Kruchinina E.V., Gorenkova O.S., Glazkova A.V., Polyakova E.Yu., Kochina N.A., Krasnoshchok E.V., Zaydieva Y.Z., Kareva E.N., Serebrova S.
Introduction. Patients with surgical menopause are at risk for an osteopenic syndrome. For adequate medical correction of osteoporosis, it is necessary to clarify the mechanisms of the pathogenesis of this condition. It is known that osteoclasts, the activatio…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2019
Tolibova G.H., Tral T.G., Tatsiy I.D., Kleimenova T.S., Kvetnoy I.M.
Introduction. The endometrial hyperplasia is a current problem in connection with the high frequency in reproductive-aged patients with infertility associated with external genital endometriosis and uterine myoma. The aim of the study was the comparative evalu…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2019
Polyakova V.O., Gazitaeva Z.I., Kleimenova T.S., Drobintseva A.O., Prokopov A.Yu., Kvetnoy I.M.
Introduction. Skin aging is a natural process that cannot be stopped. However, there are many ways to help stop premature aging of the skin and reduce the signs that have already appeared. One of them is the subcutaneous administration of preparations containi…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2019
Bystrova E.Yu., Platonova O.N., Shpanskaya A.A., Dvornikova K.A., Nozdrachev A.D.
Introduction. At present, signaling pathways involved in the development of innate and adaptive immune responses and comprising, inter alia, the interaction of pattern-recognizing receptors, such as TLR, with antimicrobial peptides associated with inflammation…
ОБЗОР2019
Dvornikova K.A., Bystrova E.Yu., Platonova O.N., Nozdrachev A.D.
Introduction. In recent years, there have been aroused and actively studied mutations associated with Toll-like receptor genes (TLRs). The emerging interest is related to the identification of many associations between the TLRs polymorphism and the development…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2018
Bragina O.D., Vorobyeva A.G., Tolmachev V.M., Orlova A.M., Chernov V.I., Deev S.M., Proshkina G.N., Shulga A.A., Larkina M.S., Zelchan R.V., Sinilkin I.G., Medvedeva A.A.
Introduction. Her2/neu is one of the most studied molecular target the overexpression of which is associated with poor prognosis and aggressive course of the disease. The use of modern non-invasive radionuclide techniques with the application of highly affinit…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2018
Spirina L.V., Kondakova I.V., Yurmazov Z.A., Usynin Е.А., Slonimskaya Е.М.
Introduction. The study of molecular mechanisms of the development of kidney cancer is one of the actual problems in oncology. There is conflicting information about the importance of steroid hormone receptors in the kidney cancer. The aim of the study was to …
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2018
Bazhenova L.G., Gulyayeva L.F., Shramko S.V.
Introduction. Myoma occupies a leading place in the structure of gynecological diseases, reduces the fertility rate and living standardsin females of reproductive age. In 85% cases myoma is combined with adenomyosis, which complicates the treatment and increas…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2018
Matyushkina D.S., Pobeguts O.V., Bukato O.N., Rakitina D.V., Baikova Yu.P., Ladygina V.G., Andreev D.N., Maev I.V., Scherbakov P.L., Govorun V.M.
Introduction. A possible pathogenesis for Crohn’s disease (CD) involves the provocation of uncontrollable immune response by intestinal microbiota. Escherichia coli is regarded as a candidate for possible pathogen, since its content is increased in intestine o…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2018
Kryzhanovskii S.A., Antipova T.A., Tsorin I.B., Pekeldina E.S., Nicolaev S.V., Sorokina A.V., Miroshkina I.A., Gudasheva T.A., Seredenin S.B.
Aim. The study of the angiotropic activity of dipeptide mimetics of the nerve growth factor (NGF) loop 4 possessing properties of TrkA receptor agonists and antagonists. Methods. Experiments in vitro. Angiotropic effects of dipeptide mimetics of the NGF loop 4…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2018
Kareva E.N., Tikhonov D.A., Kuvayeva V.D., Velichinskii R.A., Klimenko M.P.
Introduction. Low rate of the pregnancy frequency in the IVF programs is one of the challenges in gynaecology nowadays. One of the approaches to enhance the efficacy of the assisted reproductive technology is to estimate the success of the forthcoming procedur…
ОБЗОР2018
Gataulin R.G., Veselova O.M., Pisarenko O.I.
The neuropeptide galanin (Gal) is widely distributed as well in central and peripheral nervous system, as in other organs and tissues of humans and animals. Its pleotropic effect is due to an activation or inhibition of galanin specific receptors – GalR1, GalR…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Mostovich L.A., Logacheva G.P., Svyatchenko S.V., Shevchenko S.P., Gulyaeva L.F.
Introduction. Papillary thyroid cancer (PTC) is the most common malignancy of the endocrine system. As the most frequent genetic alteration BRAF V600E mutation in PTC leads to changes in the activity of intracellular signaling pathways. As a result, expression…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Emelyanov A.S., Emelyanova A.N., Vitkovsky Yu.A.
Introduction. Erysipelas is characterized by consistently high morbidity rate, pronounced tendency to recur, the frequent change of lymph circulation, formation of secondary elephantiasis and others symptoms. The prediction of the course of erysipelas is unres…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Krylova I.S., Shapkin Y.V., Polyakova V.O., Kleymenova T.S., Kvetnoy I.M.
Introduction. Fibroadenomatosis (FAM) is a heterogeneous group of pathological conditions of the mo-Nochnoi gland, with hormone-dependent nature and different degree of risk maligni of the organization. The use of routine histological stains is not enough to d…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Aylamazyan E.K., Tolibova G.Kh., Tral' T.G., Petrosyan M.A., Kleymenova T.S., Kogan I.Yu., Polyakova V.O., Kvetnoy I.M.
The study of estrogen and progesterone receptors expression remains to be the one of the major challenges in contemporary gynecology due to the high frequency of the occurrence of infertility, miscarriage and ineffective IVF cycles, hyperplasia and endometrial…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Kochetova O.V., Korytina G.F., Akhmadishina L.Z., Viktorova T.V.
Association of adrenergic receptors gene polymorphisms in overweight persons has been shown by Gagnon J. et al. in 1996. For the locus Trp64Arg (rs4994) β3-adrenoceptor gene was shown to be associated with the risk of obesity, confirmed by the works of a numbe…
ОБЗОР2017
Konstantinova E.V., Shurdumova M.Kh., Sapozhnikov A.M.
In acute focal ischemia of the heart and brain similar processes are developing despite the obvious differences in the structure, function, and blood supply of these organs. It was shown that under ischemic conditions synthesis stress induced proteins includin…