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Molecular Medicine Peer-reviewed scientific journal

Found: 52

ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015

CHARACTERISTICS OF STEROIDOGENESIS IN THE TUMOR AND SURROUNDING TISSUES IN EXPERIMENTAL MELANOMA B16

Introduction. Hormonal aspect in the pathogenesis of melanoma development is still poorly studied. Tumor transplantation to experimental animals allows to study the effect of malignant process on different systems and organs, detect the saturation of tumor and…

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ОБЗОР2015

THE PHARMACOGENETIC MECHANISMS OF DEVELOPMENT OF METABOLIC DISORDERS ASSOCIATED WITH THE SECOND-GENERATION ANTIPSYCHOTICS

Antipsychotics are the main medication for schizophrenia treatment. Recently the wideused group of them became second-generation antipsychotics (SGA). Due to that, problem of metabolic disturbances as side effect of SGA is more actually. The development of pha…

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ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015

MOLECULAR MECHANISMS OF DERMAL GEROPROTECTIVE ACTION OF DRUGS BASED BIOMIMETIC PEPTIDE

Introduction. Biomimetic peptides – are synthetic compounds which are identical to amino acid sequence that are synthesized by organizm, which can interact with growth factor receptors and provide antiaging clinical effect. The aim of the study. Investigation …

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ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015

COMPARATIVE ASSESSMENT OF GROWTH FACTORS EXPRESSION IN PIGMENT NEOPLASMS OF SKIN

Introduction. The study of growth factors in tissues of various kinds of nevi alongside with the skin melanoma can provide valuable information about the pathogenesis of the latter, determine the factors of early diagnostics of melanoma, as well as outline the…

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Research article2014

HORMONAL PATTERN OF MELANOMA AND ITS SURROUNDING TISSUES

Introduction. Skin melanoma is referred to hormone-dependent tumors, the mechanism of influence of endocrine factors on pathogenesis of the tumor, however, has not been determined so far The aim of the study. The studying of the level of steroid hormones, prol…

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Research article2014

COMPARATIVE BIOCOMPATIBILITY OF NONWOVEN POLYMER SCAFFOLDS OBTAINED BY ELECTROSPINNING AND THEIR USE FOR DEVELOPMENT OF 3D DERMAL EQUIVALENTS

Introduction. One of the most prospective approaches in therapy of deep skin burns is the development of artificial dermal equivalents with a potential to provide efficient scaffolding for dermis reconstruction and re-epithelisation. The choice of material for…

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Research article2014

INTERLEUKIN-15: THE STRUCTURE, SIGNALING AND ROLE IN THE IMMUNE PROTECTION

IL15 proves to be a cytokine that important for innate as well as for adaptive immunity. It is one of the key factors of cell-mediated antiviral response. In this review we touch upon its primary, secondary and tertiary structure and functions, characteristics…

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Research article2012

MICROFLUIDICS AND ITS PERSPECTIVES IN MEDICINE

Microfluidics can raise our sights in the biomedical area. This paper presents an overview of microfluidic systems (IFS), which is evidence of the urgency of this trend. The concept of development of the microfluidic system (MFS) and the technology of producti…

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Research article2012

INTRODUCTION OF MODIFIED mRNA hTERT, CAUSES SHORT-TERMTELOMERASE ACTIVITY IN HUMAN SKIN FIBROBLASTS

Reprogramming of human cells without genetic modification is increasingly used technology in experimental cell biology. One of these promising methods is the transfection of synthesized mRNA of transcription factors. In this study we synthesized a modified mRN…

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