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Molecular Medicine
Found: 103
Introduction. The use of genomic approaches allows a detailed studying of the pathogenetic potential of H. pylori bacteria. The aim of the study. To investigate the genome structural and functional organization of the H. pylori isolated in the Republic of Bela…
Introduction. The progression of inflammation in community-acquired pneumonia is associated with the activation of proteolytic enzymes, involved in eliminating the pathogenic agent, removing damaged structures. Proteinases are controlled by α1-proteinase inhib…
At present biomedical research is based on joint fulfillment of theoretical and experimental investigations of various derivatives of potential therapeutic destination. Well-balanced combination of noted studies is provided for the high reliability of ensemble…
Introduction. Alveococcosis is a parasitic disease associated with the formation of the liver tumor-like lesion. This parasitic tumor has infiltrative growth and the ability to metastasize, that is, it exhibits the properties of malignant tumors. The disease i…
Objective: a morphological study of the transcription factors NeuroD1, Nkx2.2, Isl1; somatostatin and chromogranin A in various forms of CH The methods included immunohistochemistry examination with antibodies to NeuroD1, insulin, somatostatin, ChrA, Nkx2.2, I…
The review summarizes a number of published reports about the influence of total hormonal and metabolic disturbances on the functioning system mother – placenta – fetus in the organism of the women with obesity and gestational diabetes mellitus. The circadian …
Introduction. The specific activity of blood coagulation factor VIIa depends, among other things, on the presence of N-acetylneuraminic acid (sialic acid) and phosphate residues in the molecule. Thus the authenticity of glycosylation profile as one efficacy an…
The purpose of this review is a systematic analysis of data from clinical observations, international experience, and reviews related to the pathogenetic aspects of the impact of a new coronavirus infection on the blood system. Information was searched in MedL…
The problems of longevity increase and its quality improvement are actual for the modern gerontology. So far it is necessary to complete tasks of early diagnostic and target prophylactic of the age-associated pathology. There are presented the data concerning …
Congenital adrenal hyperplasia (CAH) is a group of disorders caused by mutations in genes that encode steroidogenic enzymes. The most frequent form of CAH is caused by defects in CYP21A2 gene leading to 21-hydroxylase deficiency (21-OHD). There are 3 clinical …
Peptidergic structures of the hypothalamus arrange a basis of its unique ability to regulate the organism's functions in time, adjusting metabolism, energy exchange and motor activity as sources of its own energy- to the dynamics of energy intake from external…
Introduction. The initial state of an organism and its initial reactivity are the main prognostic criteria for the individual radiosensitivity evaluation. Particulars of the DNA structure and chromatin conformation determine in many respects the cell radiosens…
Introduction. Giant cell tumors (GCT) of bones are benign tumors with the potential for the aggressive course and ability to metastasize. GCT accounts for approximately 5% of all primary bone tumors. Materials and methods. The clinical case of the patient L., …
Introduction. ATP is one of the most frequently updated molecules in the organism. The presence of a transmembrane gradient of H+ electrochemical potential is a crucial condition for the synthesis of ATP using FоF1-ATP synthase enzyme, which affects proton tra…
Introduction. The endometrial hyperplasia is a current problem in connection with the high frequency in reproductive-aged patients with infertility associated with external genital endometriosis and uterine myoma. The aim of the study was the comparative evalu…
The dynamics of the collagen domain structure in the Achilles tendons and knees when they are stretched. Research method. A new non-invasive gravitational mass spectroscopy (GMS) method for operational (1...20 s) long-range order (LRO) monitoring in human tend…
Introduction. Her2/neu is one of the most studied molecular target the overexpression of which is associated with poor prognosis and aggressive course of the disease. The use of modern non-invasive radionuclide techniques with the application of highly affinit…
The review summarizes a number of the published reports about the structure of the core circadian oscillator system and the melatonin’s role as an interface of endogenous rhythms for the cyclic environment what optimizes maternal, placental and fetal physiolog…
Introduction. The use of cell technologies has particular effectiveness in the treatment of many diseases. However, the literature contains data concerning macrophages ability of a phagocytosis and lysisofautologic multipotent mesenchymal stromal cells of a bo…
Introduction. Changes in the structural organization of the cell nucleus often precede the degeneration of the nerve cell. Histone H4 trimethylated on lysine 20 (H4K20me3) may act as one of the markers of neurodegenerative processes. The aim of this paper was …