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Molecular Medicine
Found: 248
Relevance. The mechanisms of B-lymphocyte immunity are not fully understood at present, in particular, the role and significance of the humoral response to viruses. There is insufficient understanding of how B-lymphocytes are selected for differentiation into …
Introduction. The interest in neutrophil extracellular traps (NETs) in various conditions, including pregnancy complications was increased over the last decade. Accompanied by gestational diabetes mellitus (GDM) hyperglycemia contributes to neutrophil’s activa…
Introduction. Bronchial asthma is a heterogeneous disease involving different phenotypes. The allergic phenotype is the most studied model of asthma. Identification of causally significant allergens by determining allergen-specific IgE is the key to precision …
Introduction. Up to 20% of tuberculosis patients suffer from malignant neoplasms. In this case, the combination of both diseases in the lung is a particular problem. More than 60% of patients cannot complete combination therapy due to drug-resistant MBT. The a…
Currently, the diagnosis of early stages of cutaneous T-cell lymphomas (CTCL) is one of the most challenging tasks in dermatology. This review is devoted to the analysis of new immunohistochemical (IHC) markers that could be considered diagnostic for the detec…
Introduction. Nanotechnology represents an innovative direction in cancer drug development, enabling the creation of effective drug delivery systems with enhanced therapeutic properties. Objective. To analyze the main types of nanoparticles used in oncology, e…
Objective. To analyze current advances in nanotechnology applications for the development of targeted drugs in oncology, including their mechanisms of action and clinical application prospects. Material and methods. A comprehensive analysis of scientific liter…
The purpose of this review is to analyze current advances in the field of genome editing, their application for the modeling and treatment of neurodegenerative diseases, as well as to discuss current limitations and prospects for overcoming barriers in clinica…
Introduction. Immune checkpoint (IC) signaling pathways are involved in regulating the functions of T lymphocytes and NK cells, which play a key role in antitumor and antiviral control. The purpose of our study was to systematically analyze the information pre…
The development of metastases even long after treatment is one of the most important problems of medicine. There are mechanisms helping cancer cells to survive at various steps of metastasis. The ability of cancer cells to turn into dormant state characterizin…
Introduction. An important pathogenetic link in systemic inflammation in ulcerative colitis (UC) is dysregulation of the immune response. The aim of the study: to study pathogenetic changes in the serum level of interleukin (IL)-4 during UC therapy. Methods. 6…
Introduction. An actual decision of the issue of safety and effective drug therapy improvement is the development of transport systems that allow to provide targeted delivery of drugs to target cells, while reducing their toxic effects. The aim of the work was…
Studies of post-radiation lesions of the pancreas after irradiation with charged particles (electrons, protons) are few, however, electron therapy is one of the promising methods in radiobiology and can be used to model post-radiation pancreatitis. The mechani…
Aim of the study was to establish the significance of TR-receptor, P2X1-receptor and P2Y-receptor synergism for the efficiency of TC aggregation in patients with different sensitivity to non-selective NSAIDs, which will allow us to approach an understanding th…
Introduction. Lung cancer occupies a leading position in the structure of mortality from cancer. Chronic inflammation characteristic of tuberculosis increases the risk of lung cancer. Currently, more and more information is emerging confirming the cause-and-ef…
Introduction. Sequencing of single cells makes it possible to characterize the cellular and molecular composition of tissues, the state of DNA, RNA and expressed proteins. The «single-cell» sequencing method is gaining increasing popularity in modern biology a…
Introduction. Treatment of the coexistent pathology of lung cancer and tuberculosis remains the prerogative of experimental research, since the optimal treatment strategy for the coexistence of these two diseases has not yet been developed. The purpose was to …
Introduction. Late diagnosis of inflammatory pathologies leads to increased risks of chronicization of the process, generalization, development of complications, and reduced effectiveness of therapy. Routine methods of clinical laboratory diagnostics often hav…
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. The specificity of the immune microenvironment of an organ limits the possibilities of traditional therapeutic and surgical approaches to treatment, therefore one of the mo…
The use of mathematical indices of glycemic variability (IGV) opens up new possibilities in predicting diabetic complications, which allows more accurate correction of therapy and prevention of the development of acute and chronic conditions. Aim. To analyze t…