Found: 223
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2024 · pp. 34–39
Belkin A.N., Freynd G.G., Kochetov A.G.
Introduction. Alkaline phosphatase (ALP) is an enzyme from the class of hydrolases, widely present in human tissues and organs. Intestinal ALP is one of the enzyme isoforms that is expressed in the mucous membrane throughout the intestine and is a marker of in…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2024 · pp. 28–33
Novak-Bobarykina U.A., Dokhov M.A., Krylova Yu.S., Kvetnaya T.V., Paltsev M.A.
Relevance. Ectopic secretion, which occurs in the early stages of tumor development, is not only one of the first signs of a neoplasm, but can also indicate the severity of the oncological process. Purpose of the study: To evaluate the possibility of using the…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2024 · pp. 21–28
Krylova Yu.S., Kudriashov G.G., Tochilnikov G.V., Vinogradova T.I., Dokhov M.A., Yablonskii P.K.
Introduction. Lung cancer occupies a leading position in the structure of mortality from cancer. Chronic inflammation characteristic of tuberculosis increases the risk of lung cancer. Currently, more and more information is emerging confirming the cause-and-ef…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2024 · pp. 35–42
Kudriashov G.G., Zmitrichenko Yu.G., Vinogradova T.I., Dogonadze M.Z., Zabolotnyh N.V., Dyakova M.E., Esmedlyaeva D.S., Tochilnikov G.V., Nefedov A.O., Krylova Yu.S., Yablonskii P.K.
Introduction. Treatment of the coexistent pathology of lung cancer and tuberculosis remains the prerogative of experimental research, since the optimal treatment strategy for the coexistence of these two diseases has not yet been developed. The purpose was to …
ОБЗОР2024 · pp. 3–12
Bueverova E.L., Zolnikova O.Yu., Paltzev M.A.
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. The specificity of the immune microenvironment of an organ limits the possibilities of traditional therapeutic and surgical approaches to treatment, therefore one of the mo…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 22–26
Hop Do Ngoc, Mironova E.S., Kvetnoy I.M., Dokhov M.A., Paltsev M.A.
Introduction. Lung carcinoma is one of the most common cancers and the most likely cause of cancer mortality in the world. The use of the IHC method to determine the immunophenotype of tumor cells greatly facilitates the differential diagnostic search, allows …
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 40–48
Gilyazova I.R., Asadullina D.D., Ivanova E.A., Izmailov A.A., Kudlay D.A., Gilyazova G.R., Galimova E.F., Ermakov I.B., Rakhimov R.R., Popova E.V., Nasretdinov A.F., Sultanbaev A.B., Khusnutdinova E.K., Pavlov V.N.
Despite significant advance in clear cell renal cell carcinoma treatment, immune checkpoint inhibitors (ICIs) still have limited therapeutic efficacy. Taking into account the resistance to immunotherapy, observed in malignant neoplasms, the search for predicti…
ОБЗОР2023 · pp. 11–19
Sultanbaev A.V., Musin Sh.I., Menshikov K.V., Izmailov A.A., Nasretdinov A.F., Sultanbaevа N.I., Menshikova I.A., Tsimafeyeu I.V., Lipatov D.O., Sultanbaev M.V., Lipatov O.N., Kudlay D.A.
Introduction. The effectiveness of antitumor immunity is determined by various mechanisms of recognition of tumor antigens, while the diversity of the repertoire of antigenic receptors is determined by V(D)J recombinations in maturing T and B cells. The aim of…
ОБЗОР2023 · pp. 3–11
Podlesnaya P.A., Kovaleva O.V., Petrenko A.A., Kushlinskii N.E., Gratchev A.N.
This review is devoted to summarizing the available data on the expression of long non-coding RNAs (lncRNAs) in lung cancer cells and tissues, their role in tumorigenesis, association with clinical and morphological characteristics and disease prognosis. The p…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 33–38
Esimbekova A.R., Lapkina E.Z., Ruksha T.G.
Introduction. Among the heterogeneous population of tumor cells, there are so-called dormant and senescent cells located in the G0 phase of the cell cycle. The transition to the G0 phase is a stress response mediated, for example, by treatment with chemotherap…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 25–32
Kudriashov G.G., Vinogradova T.I., Zmitrichenko Yu.G., Dogonadze M.Z., Zabolotnyh N.V., Dyakova M.E., Esmedlyaeva D.S., Gavrilov P.V., Azarov A.A., Tochilnikov G.V., Nefedov A.O., Krylova Yu.S., Yablonskii P.K.
Introduction. Lung cancer and tuberculosis, make a significant affect to the morbidity and mortality of the population in Russia and in the world. Strategy of medication therapy has not been developed for cases when these diseases are combined. The aim of the …
ОБЗОР2023 · pp. 3–10
Okladnikova E.V., Zinchenko I.S., Ruksha T.G.
Introduction. Overcoming resistance to anticancer drugs in the treatment of malignant neoplasms is an urgent problem of recent decades. Unfortunately, there is no single mechanism for the development of resistance. Alterations that occur in a normal cell durin…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 56–60
Chetveryakov A.V., Tsepelev V.L.
Introduction. A high level of checkpoint co-inhibitors in the tumor microenvironment plays an important role in inhibiting the local immune response, which contributes to the growth and progression of cancer. The aim of the study. We aimed to determine immune …
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 43–49
Kudriashov G.G., Nefedov A.O., Tochilnikov G.V., Zmitrichenko Yu.G., Krylova Yu.S., Dogonadze M.Z., Gavrilov P.V., Azarov A.A., Davydenkova E.A., Vinogradova T.I., Yablonskii P.K.
Introduction. One of the problems of modern medicine is the low efficiency of treatment of patients with a coexistence of lung cancer and active tuberculosis. Optimal treatment regimens for coexistence pathology have not been developed at present. In recent ye…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2022 · pp. 44–49
Orlova N.V., Muraviov A.N., Gorelova A.А., Remezova A.N., Vinogradova T.I., Yudintceva N.M., Nashchekina Y.A., Yablonsky P.K.
The article describes the results of an experimental study of tissue-engineering constructions based on lactic acid – poly-L,L-lactide, containing allogeneic cells of various tissue origin. Aim: to show experimentally the possibility of using an allogeneic tis…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2022 · pp. 25–32
Gershtein E.S., Kuzmin Yu.B., Alferov A.A., Korotkova E.A., Tsarapaev P.V., Sokolov N.Yu., Kuznetsov I.N., Vashketova O.I., Kozlova E.M., Yanushevich O.O., Boulytcheva I.V., Stilidi I.S., Kushlinskii N.E.
Background. Low sensitivity of bone tumors to various schemes of standard chemotherapy stimulated the search of new targets for their medicamentous treatment. Among such targets are the so-called “immune checkpoints” promoting the escape of the tumor from the …
ОБЗОР2022 · pp. 12–15
Krylova Yu.S., Kudriashov G.G., Nefedov A.O., Dokhov M.A., Zakharchenko A.O., Yablonskii P.K.
The review is devoted to the analysis of modern ideas about the molecular mechanisms of tumor transformation in tuberculosis; signal molecules are described, which may be biomarkers and targets for optimizing personalized diagnosis and targeted therapy of the …
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2022 · pp. 28–34
Kovaleva O.V., Zybina N.N., Gratchev A.N., Chang V.L., Ognerubov N.A., Stilidi I.S., Kushlinskii N.E.
Introduction. Stomach cancer in Russia occupies the 4th place among most frequent malignant neoplasms, after tumors of the lung, breast and colon. The search for new diagnostic and prognostic markers of this pathology is an urgent task of modern molecular onco…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2022 · pp. 34–40
Koroleva E.I., Musaelyan A.A., Nazarov V.D., Lapin S.V., Vorobev S.L., Sharova O.L., Kozorezova E.S., Korablina I.M., Emanuel V.L., Orlov S.V.
Introduction. In 2013 The Cancer Genome Atlas research group divided the molecular aberrations in endometrial cancer into four subtypes: POLE mutations, microsatellite instability, copy-number low and copy-number high. These subtypes have different prognosis a…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2022 · pp. 20–29
Lyubimova N.V., Kuzminov A.E., Lebedeva A.V., Timofeev Yu.S., Toms M.G., Stilidi I.S., Kushlinskii N.E.
Introduction. Small cell lung cancer (SCLS) is a highly aggressive type of tumor, and various compounds are considered as potential biochemical markers of its prognosis, including neuron-specific enolase (NSE), chromogranin A (CgA), and prograstrin releasing p…