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Molecular Medicine
Found: 49
Introduction. Progress in the treatment of cancer and bone tumors including, is associated with a significant breakthrough in molecular biology, immunology, understanding the causes of the emergence of the tumor cell, patterns of the development and course of …
Introduction. P16INK4a protein plays one of the key role in processes of cell proliferation, its inactivation is noted in a number of tumors of various localization. Restoration of the p16INK4a function in neoplastic cells may promote braking of division of tu…
Introduction. Interactions of exposed on the tumor cell surface or circulating in the bloodstream molecules MICA with activating receptor NKG2D play an important role in the regulation of antitumor immune response. Accumulation of soluble MICA compromises NKG2…
Introduction. A novel 3S-paradigm of alternative experimental anti-cancer drug testing procedure was developed in parallel with a modern conception of personalized and predictive medicine to reveal both positive and negative effect in each experiment and topre…
Targeted delivery of anticancer drugs is a new direction aimed to delivery preparations capable of enhancing selectivity of action of drugs owing to the use of vector molecules. Targeted drug delivery system is the construction that includes three components: …
The modern strategies of chemotherapy of metastatic colorectal cancer (CRC) based on the combination of cytotoxic and targeted angents resulted in significant increase of patient’s life duration. To study the action of anti-EGFR agents (panitumumab), which blo…
To study the correlation of proliferative activity of tumor cells with clinical and morphological parameters and indices of survival rates a retrospective clinical and morphological analysis of 60 cases of localized and metastatic neuroendocrine tumors (NETs) …
In this review the recent data regarding cancer stem cells (CSCs), the mechanisms of their drug resistance and the development of novel anti-CSC therapies are summarized. Recent studies suggest that salinomycin has selective toxicity for CSCs. Salinomycin is a…
Introduction. To this date the search for new substances with antitumor activity is an urgent task of pharmacology and medicine. Carrageenans are sulfated galactans of red algae, they are promising substances for the basis of future drugs, as well as for the c…