This website is intended for professionals in medicine and healthcare. By selecting “Confirm”, I declare that I am a member of this professional audience. I also agree to the publisher’s rules for using its information resource. Publisher’s resource rules (Russian)
Molecular Medicine
Found: 690
Introduction. Clinical observations have revealed that the treatment of schizophrenia with the use of chlorpromazine (CPZ) impairs cognitive processes. Whether it is possible to eliminate these side effects of CPZ? The aim of the study. The aim of our study wa…
Introduction. Ambient air pollution is important worldwide problem. Numerous studies have found associations between air pollution and respiratory diseases, cardiovascular diseases, diabetes, and infant mortality. Children are more susceptible to the air pollu…
Introduction. The ACTA2 gene encodes α-actin in aortic smooth muscle cells, and its mutations may cause thoracic aortic aneurysms. Analysis of ACTA2 polymorphism can be used in a complex risk assessment of non-familial thoracic aortic aneurysms. The aim of the…
Aim. To investigate the possible association between XRCC1 Arg399Gln and p53 Arg72Pro polymorphism and the risk of breast cancer (BC) risk in Kyrgyz women. Methods. The XRCC1 Arg399Gln and p53 Arg72Pro genotypes were determined with the use of the polymerase c…
Introduction. Tumor necrosis factor (TNF) plays a central role in the development of inflammatory and neoplastic processes. In the TNF gene promoter region there are -308(g/a) and -238(G/A) polymorphisms with different influence on the level of expression of T…
Introduction. Currently, in the pathogenesis of various diseases have been intensively studied the structure and function of innate immune receptors, a special role played by a Toll-like receptors (TLR). In the recent literature there are no comprehensive stud…
Retinal vascular occlusion is one of the most severe vascular lesions of the eye, leading to permanent disability. Approximately 16 million adults in the world have this pathology at the age over 40 years. Typically, the disease occurs acutely as a result of m…
This review covers current concepts on the structure, function, regulation of translation and post-translational modifications of hypoxiainducible factor 1 (HIF-1). In addition, the role of this transcription factor in hypoxia and ischemia is discussed. We foc…
The main purpose of the treatment of bronchial asthma is achievement and maintenance of the control over the symptoms of disease at optimal level. For this purpose in terms of basic therapy there is used inhalation of as glucocorticosteroids as well systemic g…
Introduction. Currently there was described a number of subpopulations of haematopoietic stem cells and progenitor cells, important for completeness of the recovery of hematopoiesis and antigens involved in the process of homing, adhesion and mobilization of h…
Introduction. Gastric cancer is a global problem for the health systems worldwide. Today it takes the fourth place in the world in the morbidity and the second place in the mortality structure. In Russian Federation, almost 70% of gastric cancer cases are diag…
Introduction. Mediator release from mast cells or basophils is the key event in many acute allergic and inflammatory processes. Rat basophilic leukemia cell line RBL-2H3 cells is widely used as a model for studying mast cells degranulation. Aim of the study. T…
Introduction. Study of growth factors content in tumors of different localizations and assessment of their probable correlation with the main clinical and morphological characteristics are relevant nowadays. Products of expression of the viral genome – E7 and …
Introduction. Glatiramer acetate (GA, copaxone) – is an immunomodulatory drug, used for reducing the progression of multiple sclerosis. The absence of optimal therapeutic effect in some cases determines the necessity to search the prognostic markers of GA effi…
The purpose of this study. Evaluation the effect of Afobazol on the level of myocardial inducible NO-synthase (iNOS) in the ischemic myocardium in rats. Methods. Myocardial ischemia was produced by the Selye’s method. The of inducible NO-synthase level on the …
The literature review provides information on the molecular biology of low-grade malignancy gliomas (LGMG) in children and adolescents. The data on specific genetic aberrations in pilocytic astrocytoma, pleomorphic xantoastrocytoma, subependimal giant cell ast…
Introduction. Binding of the human immunodeficiency virus (HIV) envelope gp120 glycoprotein to CD4 and CCR5 receptors on the cell membrane initiates the viral entry process. Simultaneous expression of these two receptors has been observed on T-lymphocytes, mon…
Introduction. Short-term and long-term memory impairments are the main symptoms of several socially important neurodegenerative disorders, such as Alzheimer disease. For this purpose the pharmacological enhancement of short-term memory is of great interest. No…
Introduction. SLCO1B1 encodes the organic anion-transporting polypeptide which has been shown to regulate the hepatic uptake of statins. SLCO1B1*5 genetic variant is associated with the high risk for statin-induced myopathy in patients with statins therapy. Ai…
Introduction. Endometritis and elder fertile age are the one of the main reason of infertility. Molecular methods of endometrial investigation have opened new perspectives in diagnostics and evaluation of the efficacy of the management of endometritis Objectiv…