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Molecular Medicine
Found: 117
Peptidergic structures of the hypothalamus arrange a basis of its unique ability to regulate the organism's functions in time, adjusting metabolism, energy exchange and motor activity as sources of its own energy- to the dynamics of energy intake from external…
Introduction. The correct functioning of the circulatory system allows providing stability of the brain and prevents the progression of pathological processes. The search for prognostic markers which make it possible to predict the appearance and adverse cours…
Introduction. Giant cell tumors (GCT) of bones are benign tumors with the potential for the aggressive course and ability to metastasize. GCT accounts for approximately 5% of all primary bone tumors. Materials and methods. The clinical case of the patient L., …
Introduction. Type 2 diabetes mellitus (DM) is a metabolic disease characterized by prolonged hyperglycemia, which can cause various complications. Some studies have reported on the relationship between changes in cerebral metabolism and glucose levels. The ai…
Background. Genotyping of the tumor samples is necessary for a personalized approach in the treatment of patients with malignancies. The identification of somatic mutations in EGFR and KRAS genes can help to predict the course of the disease and to individuali…
Micro-RNAs are a group of small non-coding RNA molecules regulating target genes at the post-transcriptional level. Micro-RNAs are involved in the control of many pathophysiological processes, including dyslipidemia, the main risk factor for atherosclerosis. C…
Introduction. The widespread cellular technologies will sooner or later lead inevitably to the introduction of multipotent mesenchymal stromal cells (MMSC) or their exosomes to patients who have implanted artificial materials in their organism. The engraftment…
The review summarizes a number of the published reports about the structure of the core circadian oscillator system and the melatonin’s role as an interface of endogenous rhythms for the cyclic environment what optimizes maternal, placental and fetal physiolog…
Introduction. Apolipoprotein-E (apoE), being one of the metabolically active apoproteins plays the important role in lipid metabolism. The aim of the study was to investigate the quantitative distribution of apoE between different lipoprotein classes in health…
Introduction. Age-related macular degeneration (AMD), in particular, its exudative form, has for many years held a leading position in the causes of the loss of visual acuity and leads to blindness in 90% of elderly cases. The loss of central vision is based o…
Introduction.The telomerase activity is a universal marker for 85% of malignant tumors. This allows us to develop modern highly sensitive and highly specific kits for the diagnosis of most malignant tumors, including early stages of the disease. Existing metho…
Introduction. Despite the continuous improvement of the surgical method of treatment of patients with non-small cell lung cancer (NSCLC), there is no noticeable tendency to improve survival data. This 5-year index does not exceed 15–25%. In this regard, it is …
The aim of this work was to study the effect of methotrexate, glucocorticoids and nonsteroidal anti-inflammatory drugs on the plasma levels of nitric oxide metabolites, as well as the level of NOS2 gene transcripts in peripheral blood leukocytes (PBL) in rheum…
Diagnosis and determination of tumor process in patients with prostate cancer are the most urgent problems of modern оncology. Prostate-specific membrane antigen (PSMA) is one of the most promising molecular targets for the diagnosis of prostate cancer. The le…
Introduction. Interaction of prosthetic devices with surrounding tissues is based on protein absorption. Protein adsorption is the first stage of the interaction between prosthetic materials with tissues in the body. The number, composition, conformation chang…
Aim of the study. To study trimetazidine cardioprotective effects on the translation model of alcoholic cardiomyopathy Materials and methods. Alcoholic cardiomyopathy was reproduced in white mongrel male rats used as the sole source of liquid 10% ethanol solut…
Introduction. Carrier protein OATP1B1, encoded by the SLCO1B1gene, is involved in the transport of simvastatin into liver cells. SLCO1B1 gene polymorphisms influence on the functionality of the transporter, which could reflect on the efficacy and safety of tre…
Introduction. Search for correct markers for diagnosis, prognosis and evaluation of the effectiveness of chemotherapy is the most important problem of the modern oncohematology. The aim. To determine the clinical relevance of matrix metalloproteinase-2 (MMP-2)…
Introduction. At the preoperative stage, the leading diagnostic method for nodular thyroid lesions today is a fine-needle aspiration biopsy (FNAB). However the use of FNAB can provide the relatively high portion of poor-information samples (up to 30%) due to t…
Calbindin 28 kDa, calretinin and parvalbumin are referred to calcium-binding proteins which are both widely distributed in the nervous system and selectively expressed in certain population of neurons. These proteins are expressed not only in the central nervo…