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Molecular Medicine
Found: 338
Introduction. Proinflammatory cytokines produced in elevated concentrations in the elderly significantly impair neurogenesis in the dentate gyrus of the hippocampus, long-term potentiality, alter neuronal morphology and function, and increase apoptosis. This l…
Introduction. Among the heterogeneous population of tumor cells, there are so-called dormant and senescent cells located in the G0 phase of the cell cycle. The transition to the G0 phase is a stress response mediated, for example, by treatment with chemotherap…
Results. During the analysis of the published pathogenesis of celiac disease (CD) is actively discussed. It is assumed that the change in gluten tolerance is formed under the influence of a number of different factors, including genetic predisposition and envi…
Introduction. Overcoming resistance to anticancer drugs in the treatment of malignant neoplasms is an urgent problem of recent decades. Unfortunately, there is no single mechanism for the development of resistance. Alterations that occur in a normal cell durin…
Introduction. A high level of checkpoint co-inhibitors in the tumor microenvironment plays an important role in inhibiting the local immune response, which contributes to the growth and progression of cancer. The aim of the study. We aimed to determine immune …
Relevance: COVID-19 is the accepted name for an acute respiratory disease caused by the SARS-CoV-2 coronavirus. The suddenness, speed of spread, severity, and high lethality of COVID-19 have led many of the drugs used in the early stages of a pandemic to be ba…
The article describes the results of an experimental study of tissue-engineering constructions based on lactic acid – poly-L,L-lactide, containing allogeneic cells of various tissue origin. Aim: to show experimentally the possibility of using an allogeneic tis…
Mitochondria are the active cell organelles whose structures (the membrane in particular) express a large number of signaling molecules, proteins mainly, that play an important regulatory role in cell active functioning. The biological activity of mitochondria…
Introduction. In Kyrgyzstan about 60% of the adult population suffers from lipid metabolism disorders of varying degrees. Early identification of persons at increased risk of developing obesity is of great importance, which can be achieved through the study of…
Introduction. Violation of the skin barrier can be considered as an initial stage in the development of atopic dermatitis, leading to further skin inflammation [2]. Transmembrane proteins such as claudin-1, claudin-7, occludin and E-cadherin are known to be th…
Introduction. Endometriosis is a chronic inflammatory estrogen-dependent disease characterized by the presence of endometrial tissue outside the uterine cavity. The pathogenesis of endometriosis is not fully determined. The relevance of its study is due to the…
Relevance: The review is devoted to the analyses of literature data on disorders of the immune system in COVID-19. Since some of the clinical symptoms of COVID-19 are consistent with those of autoimmune diseases, one of the fundamental questions about COVID-19…
Аim of the study was to evaluate the activity of receptors that control contraction (α2-adrenergic receptor, purine P2X1 and P2Y receptors, angiotensin AT1 receptor, TxA2 receptor) and relaxation of smooth myocytes (adenosine A2 receptor) during standard litho…
Introduction. An increase in the number of patients with atopic dermatitis (AD) among pregnant women is recorded annually. However, the pathogenesis of AD during pregnancy is not fully understood. Exacerbations of AD during pregnancy require in-depth study, si…
Tripeptides are physiological products of protein degradation and informational molecules. AED (Ala-Glu-Asp), EDR (Glu-Asp-Arg), EDG (Glu-Asp-Gly) peptides have geroprotective, neuroprotective, reparative and antioxidant properties. The aim of the work is to e…
It is currently being discussed that the microbiota of the gastrointestinal tract and its metabolites affect the course of bronchial asthma (BA). The purpose to summarize the available data on the role of the intestinal microbiota in the pathogenesis of ВА. Ma…
The review is devoted to the analysis of modern ideas about the molecular mechanisms of the pathogenesis of sarcoidosis, it describes the signaling molecules involved in the development of sarcoidosis, which can be biomarkers and targets for optimizing persona…
The purpose of this review was to determine the role of physical activity as an integral component of environmental enrichment in the processes of neurogenesis in the rodent hippocampus. Material and methods. The full-text search has been carried out in the Me…
The senescence-associated secretory phenotype (SASP) is one of the causes of age-associated diseases, including atherosclerosis. The purpose of the review is to analyze data on the role of SASP cells of the cardiovascular system in the pathogenesis and pharmac…
Background. Protein 4-1BB (CD137) enhances the activity of T-cells, prevents their death, and promotes the production of cytokines, which makes it a powerful co-stimulating agent. Currently, the use of this glycoprotein is being studied in order to influence t…