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Molecular Medicine
Found: 207
Introduction: Great progress has been made in the treatment of arterial hypertension (AH). However, despite the fact that new technologies have paved the way for practical medicine, the number of deaths and disabilities from diseases of the cardiovascular syst…
Introduction. Assessment of the status of iron at the individual and population level is an urgent task. However, the interpretation of the results is associated with a number of difficulties. The inflammatory process, disorders of carbohydrate metabolism and …
Introduction. Primary immunodeficiency states (PIDs) are a heterogeneous group of innate immune disorders. A feature of the clinical manifestations of PID is that they are nonspecific for specific clinical forms. With untimely diagnosis and the absence of path…
The review is devoted to the analysis of modern ideas about the molecular mechanisms of the development of ferroptosis; the main conditions for the development of this type of cell death are described, and cell markers and targets for the induction of ferropto…
Relevance: COVID-19 is the accepted name for an acute respiratory disease caused by the SARS-CoV-2 coronavirus. The suddenness, speed of spread, severity, and high lethality of COVID-19 have led many of the drugs used in the early stages of a pandemic to be ba…
One of the most important tasks of modern medicine is to recognize diseases at the preclinical stage, as well as to assess their development risks and their possible prevention. This dictates the need to use new, modern technologies aimed at the early detectio…
Background. Low sensitivity of bone tumors to various schemes of standard chemotherapy stimulated the search of new targets for their medicamentous treatment. Among such targets are the so-called “immune checkpoints” promoting the escape of the tumor from the …
The review is devoted to the analysis of modern ideas about the molecular mechanisms of tumor transformation in tuberculosis; signal molecules are described, which may be biomarkers and targets for optimizing personalized diagnosis and targeted therapy of the …
Introduction. In Kyrgyzstan about 60% of the adult population suffers from lipid metabolism disorders of varying degrees. Early identification of persons at increased risk of developing obesity is of great importance, which can be achieved through the study of…
Introduction. Violation of the skin barrier can be considered as an initial stage in the development of atopic dermatitis, leading to further skin inflammation [2]. Transmembrane proteins such as claudin-1, claudin-7, occludin and E-cadherin are known to be th…
Introduction. Stomach cancer in Russia occupies the 4th place among most frequent malignant neoplasms, after tumors of the lung, breast and colon. The search for new diagnostic and prognostic markers of this pathology is an urgent task of modern molecular onco…
Introduction. The creation of peptide bioregulators that contribute to the preservation of the basic physiological functions of the body is an urgent task of modern biology and medicine. The aim of the study was to evaluate the effect of polypeptide complexes …
Introduction. In 2013 The Cancer Genome Atlas research group divided the molecular aberrations in endometrial cancer into four subtypes: POLE mutations, microsatellite instability, copy-number low and copy-number high. These subtypes have different prognosis a…
Introduction. Small cell lung cancer (SCLS) is a highly aggressive type of tumor, and various compounds are considered as potential biochemical markers of its prognosis, including neuron-specific enolase (NSE), chromogranin A (CgA), and prograstrin releasing p…
The review is devoted to the analysis of modern ideas about the molecular mechanisms of the pathogenesis of sarcoidosis, it describes the signaling molecules involved in the development of sarcoidosis, which can be biomarkers and targets for optimizing persona…
Introduction. Buccal epithelium (BE), in which cells the expression of signal molecules reflecting the state of homeostasis of the body in normal and pathological conditions is verified, is used as a diagnostic material for a number of diseases in adults. The …
Introduction. Oxidative stress and mitochondrial dysfunction are observed in virtually any disease associated with premature aging. Signaling molecules produced by mitochondria can act as specific targets for the action of pharmacological agents in order to re…
Introduction. Mitochondria are one of the most important cellular organelles that provide cells with energy, take part in cellular renewal and the implementation of endogenous mechanisms of cellular immunity. The study of the structural and functional organiza…
Introduction. Early diagnostics of such oncological disease as cutaneous malignant melanoma is strictly important for the decrease of mortality. It is known that microRNA expression in melanoma cells and in bening melanocytic nevi is different, that can be use…
Introduction. The work is devoted to study of new medication Novacutan SBio and Novacutan YBio as potential geroprotectors for biorevitalization of the skin. Klotho was used as a marker – to assess the overall aging of cells; MTH1 – the antioxidant status of c…