This website is intended for professionals in medicine and healthcare. By selecting “Confirm”, I declare that I am a member of this professional audience. I also agree to the publisher’s rules for using its information resource. Publisher’s resource rules (Russian)
Molecular Medicine
Found: 841
Introduction. SLCO1B1 encodes the organic anion-transporting polypeptide which has been shown to regulate the hepatic uptake of statins. SLCO1B1*5 genetic variant is associated with the high risk for statin-induced myopathy in patients with statins therapy. Ai…
Introduction. Endometritis and elder fertile age are the one of the main reason of infertility. Molecular methods of endometrial investigation have opened new perspectives in diagnostics and evaluation of the efficacy of the management of endometritis Objectiv…
Introduction. The influence of widespread, often long-lasting infections like herpes simplex virus (HSV), cytomegalovirus (CMV) and chlamydia infections on endocrine profile in organs of reproductive system and the role of infections in pathogenesis of uterine…
Introduction. RANK/RANKL/OPG ligand-receptor system is a key player in bone tissue homeostasis directly regulating osteoclast differentiation and osteolysis. Many pathologic processes imposed by impairments in bone remodeling including tumor growth and metasta…
The purpose of research. The study of the features of the left ventricle remodeling in the acutest stage of experimental myocardial infarction and the possibility of the correction of detected injuries. Methods. Experimental myocardial infarction in rats was i…
Introduction. The biologic behaviour of the tumor can be determined by both its own characteristics including ploidity of the tumor cells and peculiarities of its lymphocytic and cytokine microenvironment, in particular. The aim of the study. To perform a comp…
Introduction. Nitric oxide is a well-known regulator of different metabolic processes in cells and tissues. Its effect is usually represented as a balanced combination of both mediator and toxic action and the mutual ranges of them are not simply identified. I…
Objective. To study the distribution of PTPN22, TNFAIP3, CTLA4, TNFA, IL-6, IL-6R, IL-10, MCP-1, ICAM1 alleles and genotypes in early rheumatoid arthritis (eRA) patients and controls, and assess their value as potential molecular-genetic markers of predisposit…
Review is devoted to systems for drug delivery of biologically active substances in the tissues and organs of the target cells, which is relevant to medicine. There are described properties of mesenchymal stromal cells (MSCs), which many authors propose to use…
MicroRNAs (miRNAs) – small non-coding RNAs targeting multiple mRNAs – are posttranscriptional regulators of gene expression involved in carcinogenesis, metastasis, and invasion. MiRNAs expression is altered in various human tumors including ovarian cancer. Ana…
Introduction. Glaucoma is associated with a progressive decrease of visual functions, leading to blindness. One of the important factors is the outflow of the ocular fluid. А genetic association study has identified a sequence variant at the chromosome 7q31 (r…
The aim of the study. The clinical study of the efficacy and safety of the novel pharmaceutical composition Cervicon-DIM on the base of diindolylmethane (DIM) in vaginal suppository form in the course of the conservative treatment of cervical intraepithelial n…
Genes encoding proteins of IAP (Inhibitor of apoptosis proteins) have increased expression in the cells of malignant tumors of different localizations. IAPs perform several functions related to the viability of cancer cells and their subsequent proliferation. …
The review is devoted to problems of quality assessment of recombinant coagulation factors approved in the Russian Federation. The list of recombinant blood coagulation factor products approved in the world was provided. Benefits of the use of recombinant bloo…
Introduction. Currently in the world there are conducted numerous studies on the search for biomarkers associated with increased risk of coronary heart disease (CHD). The aim of the study. The study of the levels of such inflammatory biomarkers as the tumor ne…
Introduction. Oxidative stress is developed as a result of imbalance between the generation of reactive oxygen species and activity of the antioxidant defence system. This in turn results in profound changes in metabolism of lipids, proteins and nucleic acids,…
Introduction. Endometriosisis a commonovarianhormone-dependent diseasesin womenof reproductive age. Lack ofeffectiveness of treatmentof this diseasemay be associatedwith gapsof knowledgeabout the molecular mechanismsof its originand development. The aim of the…
Introduction. Genetic predispose to ischemic heart disease (CHD) are the priority directions in the study of etiological factors this condition. The aim of the study. Association analysis of polymorphism in modifying genes for blood pressure and genes for immu…
Introduction. The central role in the pathogenesis of Crohn's disease (CD) is given an immune disorder. Communication immunohistochemical characteristics of the mucous membrane with the outcome of the disease has not been studied. The aim of the study. The aim…
The aim of the study. The proof of afobazole efficacy for treatment and prevention of alcoholic cardiomyopathy and attendant complications using the previously developed translational model. Materials and methods. Alcoholic cardiomyopathy was produced by conti…