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Molecular Medicine
Found: 207
Introduction. Single nucleotide polymorphisms rs34643859 of the KCNS1 gene, rs12804550 of the SCN4B gene, and rs4514993 of the SCN11A gene were revealed in the analysis of the results of whole exome sequencing of a group of young man died by sudden cardiac dea…
Introduction. Advances in biology and medicine in particular in the field of cell technologies allow us to test eye stem cells as an alternative to surgical treatment of corneal pathology. An option to increase the resistance of stem cells to adverse microenvi…
Sarcopenia is a progressive and generalized pathology of skeletal muscles of multi-factor nature. The present review focuses on the analysis of molecular genetic markers that may contribute both to sarcopenia risk formation and the variability of diagnosticall…
Introduction. Aging is associated with a decrease in the neuro- and synaptogenesis as well as hyperactivation of glial cells, which leads to changes in the morphofunctional state of the nervous tissue of the hippocampus and, as a consequence, a deterioration i…
The neurotrophic hypothesis of depressive disorders has gained widespread recognition nowadays. This review is devoted to the brain-derived neurotrophic factor (BDNF) system in the pathogenesis of depression and major depressive disorder. We describe the struc…
The review summarizes a number of published reports about the influence of total hormonal and metabolic disturbances on the functioning system mother – placenta – fetus in the organism of the women with obesity and gestational diabetes mellitus. The circadian …
Introduction. The molecular mechanisms of the development of tumor pathology of the thyroid gland are associated with the activation of angiogenesis and the development of hypoxia, which contributes to the proliferation, invasion, and progression of the diseas…
Introduction. The development of neurodegeneration in Alzheimer’s disease is inextricably linked with oxidative stress, a marker of which is oxidative protein modification. In the tissues of the brain, cerebrospinal fluid and plasma in Alzheimer’s disease, an …
Introduction. The single-nucleotide polymorphisms rs75555045 and rs12904699 were found in the own genome-wide allelotyping as possible new molecular genetic markers of sudden cardiac death (SCD). The results obtained in such studies require verification in the…
Introduction. In vaginal infections, both microbial factor and the state of local (mucosal) immunity, determined by the immunological reactivity of the macroorganism, play an important role in the pathogenesis of an infectious process. Aim of the studying. To …
Background. Lung cancer is the most frequent cause of cancer mortality. The prevailing type is non-small cell lung cancer (NSCLC), in the treatment of which EGFR tyrosine kinase inhibitors are actively used, as well as a combination of BRAF and MEK inhibitors.…
Ulcerative colitis and Crohn’s disease represent one of the most pressing problems of modern medicine. Even though much attention paid to the development and implementation of high-tech diagnostic methods, inflammatory bowel diseases (IBD) tend to increase in …
Introduction. Revealing the relationship between the severity of oxidative stress and the activity of cathepsins in tissues (plasma and blood cells) readily available for the diagnosis of Alzheimer’s disease can be useful for understanding the pathogenesis of …
Introduction. The laboratory diagnosis of celiac disease is based on the detection of antibodies against deamidated gliadin peptides (anti-DGP), autoantibodies to tissue transglutaminase (anti-tTG) and endomysium (AEA), as well as genotyping of HLA-DQ2/8 loci.…
The task of molecular vital diagnosis is to search for peripheral tissues for the verification of biomarkers with the aim of optimization of diagnosis and evaluation of the effectiveness of treatment of socially significant diseases including cardiovascular pa…
Introduction. Inflammatory myofibroblastic neoplasm (IMN) of the spleen is extremely rare. It is often benign lesion, represented mainly by fusiform myofibroblasts and inflammatory cells (plasma, lymphocytes and eosinophilic granulocytes). Clinically, the sple…
Introduction. The correct functioning of the circulatory system allows providing stability of the brain and prevents the progression of pathological processes. The search for prognostic markers which make it possible to predict the appearance and adverse cours…
Introduction. The scale of myocardial infarction plays a key role in the prognosis of the disease. Changes in contractile activity of myocardial tissue as a result of necrosis of cardiomyocytes is the decisive factor in this issue. The aim of the study. The pu…
Personalized medicine implements new methods of molecular diagnostic for increasing the efficacy of the treatment of patients and the verification of the liability to diseases. Thus the search, development and applying modern methods and technologies of biomed…
Aim. To study the intergenic interaction and estimate the contribution of polymorphic loci p.K23E (rs5219, KCNJ11), g.15661G>T (rs1501299, ADIPOQ), p.V109D (rs2274907, ITLN1), g.2453G>A (rs7799039, LEP), g.53341C>T (rs7903146, TCF7L2), and p.P12A (rs1801282, P…