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Molecular Medicine
Found: 137
Introduction. The study of the prevalence of genetic risk factors for thrombosis-associated diseases in the indigenous population of Siberia is an important issue in current medicine. The aim of the study. The aim of this work is to study the allele frequencie…
ntroduction. The aim of this study was to determine the prevalence rate of CYP2C19 alleles, associated with the risk of the resistance to clopidogrel and the development of thrombotic complications in patients with acute coronary syndrome (ACS) from Russian an…
Currently, tuberculosis is the second leading cause of death from an infectious agent in the world and an important social and medical-biological problem. The first-line drug isoniazid is one of the most effective antituberculosisdrug, however it has a wide sp…
The headache is an important medical and social problem. Currently, genetics is the least-studied component of the pathogenesis of primary headaches. The most common forms of primary headache include migraine, tension type headache, cluster headache. This arti…
Diabetes mellitus (DM) is a dangerous challenge to the entire international community and the priority of the first order national health systems of all countries over the world. The growing level of hyperglycemia in type 2 diabetes is associated with the incr…
Introduction. Endometrial hyperplasia represents a chronic progressive disease characterized by high prevalence among women in older age groups. The aim of the study. To study the involvement of combinations of candidate genes in the formation of hyperplastic …
The data concerning the changes of expression and posttranslational modification of the human protein under the influence of the external and internal irradiation in vivo and in vitro are presented in this review. The investigation of protein expression and po…
Introduction. Fibroadenomatosis (FAM) is a heterogeneous group of pathological conditions of the mo-Nochnoi gland, with hormone-dependent nature and different degree of risk maligni of the organization. The use of routine histological stains is not enough to d…
Introduction. Recurrent miscarriage (RM) – a prevalent pathology in women. However, the mechanisms of its occurrence are studied insufficiently. A genetic factor may be one of the causes of RM in women. The aim of the study was to investigate the association o…
Association of adrenergic receptors gene polymorphisms in overweight persons has been shown by Gagnon J. et al. in 1996. For the locus Trp64Arg (rs4994) β3-adrenoceptor gene was shown to be associated with the risk of obesity, confirmed by the works of a numbe…
Introduction. Valvular calcification precedes the development of valvular stenosis. Currently, there being no way to effectively prevent the valvular heart disease progression, and valve replacement remains to be the only treatment option. Aim. To investigate …
Introduction. Pathogenesis of infective endocarditis (IE) is not quite clear till now. In last years research of variants of the genes connected with pathogenesis of IE was performed. The aim. The investigation of IE association with gene single-nucleotide pol…
Introduction. Hepatitis C virus (HCV) is a major risk factor for chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Molecular mechanisms of fibrogenesis are associated with the activation or inhibition of signaling pathways, which are controlling…
Introduction. Atherosclerosis, manifesting itself as acute coronary syndrome, stroke, and peripheral artery disease, is a chronic progressive inflammatory disease driven by both innate and adaptive immunity. As Triggering Receptor Expressed on Myeloid Cells-1 …
In the presented review a new potential risk factor for atherosclerosis and cardiovascular disease such as microflora of the human gastrointestinal tract is considered. The modern concept of lipid metabolism and its effects on human health outlining the basic …
Introduction. Osteoartitis (OA) is the polyetiological disease pathogenesis of which is not fully understood. One of the risk factors for osteoarthritis may be connective tissue dysplasia, which is based on genetic defects of cartilage structures. The aim is t…
Alzheimer's disease being the socially significant neurodegenerative disease of the elderly, ranks 6th on the causes of death among somatic pathologies. The molecular mechanisms of Alzheimer's disease still remain unexplored until the end, and the efficacy of …
The aim of this work was to study the relationship between adiponectin gene polymorphisms G276T with obesity and obesity-related diseases in the Kyrgyz population. Material and methods. We genotyped 288 Kyrgyz subjects (143 women and 145 men; age range: 30–75 …
Introduction. Determination of the role of genetic markers in the formation of individual susceptibility to the effects of harmful chemicals both opens up new possibilities for assessing the risk of occupational and production-related diseases and address prev…
Introduction. High rate of non-developing pregnancy in the structure of reproductive loss dictates the need to identify the etiological factors of this disease at different levels of organization of alive matter. The aim of the study. The search for associatio…