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Molecular Medicine
Found: 199
Retinal vascular occlusion is one of the most severe vascular lesions of the eye, leading to permanent disability. Approximately 16 million adults in the world have this pathology at the age over 40 years. Typically, the disease occurs acutely as a result of m…
This review covers current concepts on the structure, function, regulation of translation and post-translational modifications of hypoxiainducible factor 1 (HIF-1). In addition, the role of this transcription factor in hypoxia and ischemia is discussed. We foc…
The purpose of the study was to analyze publications on circulating tumor cells and to conduct our own research. Detection of circulating tumor cells was made in 60 patients with colorectal cancer and resectable metastatic liver lesion Т2-4N0-1M1 on the tenth …
The main purpose of the treatment of bronchial asthma is achievement and maintenance of the control over the symptoms of disease at optimal level. For this purpose in terms of basic therapy there is used inhalation of as glucocorticosteroids as well systemic g…
The review highlights the problem of the influence of the genetic characteristics of patients in the dosage of anticoagulant drugs, the main adverse reaction of taking of which is the internal bleeding. Therapy with anticoagulant drugs is characterized by a wi…
Introduction. Currently there was described a number of subpopulations of haematopoietic stem cells and progenitor cells, important for completeness of the recovery of hematopoiesis and antigens involved in the process of homing, adhesion and mobilization of h…
Introduction. Gastric cancer is a global problem for the health systems worldwide. Today it takes the fourth place in the world in the morbidity and the second place in the mortality structure. In Russian Federation, almost 70% of gastric cancer cases are diag…
Introduction. Mediator release from mast cells or basophils is the key event in many acute allergic and inflammatory processes. Rat basophilic leukemia cell line RBL-2H3 cells is widely used as a model for studying mast cells degranulation. Aim of the study. T…
Introduction. Study of growth factors content in tumors of different localizations and assessment of their probable correlation with the main clinical and morphological characteristics are relevant nowadays. Products of expression of the viral genome – E7 and …
Introduction. Immunologic microenvironment of malignant tumors is likely to be significant in «tumor-host» interaction. The aim of the study. Сomparative analysis of systemic and local factors of cellular and humoral immunity in patients with ascitic forms of …
Introduction. Glatiramer acetate (GA, copaxone) – is an immunomodulatory drug, used for reducing the progression of multiple sclerosis. The absence of optimal therapeutic effect in some cases determines the necessity to search the prognostic markers of GA effi…
The purpose of this study. Evaluation the effect of Afobazol on the level of myocardial inducible NO-synthase (iNOS) in the ischemic myocardium in rats. Methods. Myocardial ischemia was produced by the Selye’s method. The of inducible NO-synthase level on the …
The literature review provides information on the molecular biology of low-grade malignancy gliomas (LGMG) in children and adolescents. The data on specific genetic aberrations in pilocytic astrocytoma, pleomorphic xantoastrocytoma, subependimal giant cell ast…
The problem of the treatment of hyperplastic diseases of endometrium currently remains to be a matter of interest. Existing methods of hormone therapy fail to differ in high efficacy. Authors tried to find out reasons for the lack of success of hormonal manage…
Introduction. Binding of the human immunodeficiency virus (HIV) envelope gp120 glycoprotein to CD4 and CCR5 receptors on the cell membrane initiates the viral entry process. Simultaneous expression of these two receptors has been observed on T-lymphocytes, mon…
Introduction. Short-term and long-term memory impairments are the main symptoms of several socially important neurodegenerative disorders, such as Alzheimer disease. For this purpose the pharmacological enhancement of short-term memory is of great interest. No…
Introduction. SLCO1B1 encodes the organic anion-transporting polypeptide which has been shown to regulate the hepatic uptake of statins. SLCO1B1*5 genetic variant is associated with the high risk for statin-induced myopathy in patients with statins therapy. Ai…
Introduction. Endometritis and elder fertile age are the one of the main reason of infertility. Molecular methods of endometrial investigation have opened new perspectives in diagnostics and evaluation of the efficacy of the management of endometritis Objectiv…
Introduction. The influence of widespread, often long-lasting infections like herpes simplex virus (HSV), cytomegalovirus (CMV) and chlamydia infections on endocrine profile in organs of reproductive system and the role of infections in pathogenesis of uterine…
Introduction. RANK/RANKL/OPG ligand-receptor system is a key player in bone tissue homeostasis directly regulating osteoclast differentiation and osteolysis. Many pathologic processes imposed by impairments in bone remodeling including tumor growth and metasta…