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Molecular Medicine
Found: 841
Introduction. Cancer cell drug resistance in melanoma is associated with evasion of apoptosis-induced stimuli. Assessing the level of expression of the BCL2 and SIRT1 genes in distant organs and the tumor node makes it possible to assess the resistance of mela…
Introduction. As is known, changes in the nail, as an appendage of the skin, can be genetically determined, caused by injuries, diseases, medications or exposure to harmful substances. Installation of partial or complete dentures may be required for any form o…
Introduction. An urgent problem in biology and medicine is the identification of biologically active molecules that affect the cellular processes of proliferation and apoptosis in various tissues of the body. Purpose of the study. The purpose of this study was…
Introduction. Ferroptosis is a type of programmed cell death associated with excessive accumulation of endogenous iron in the cell, accompanied by the production of reactive oxygen species and, as a result, lipid peroxidation. The literature review examines th…
Dysfunction of the epidermal barrier plays an important role in the development of skin inflammatory processes. Pathological changes in the intracellular composition of keratinocytes are an integral part of the modern understanding of the pathogenesis of atopi…
Introduction. The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor that is highly expressed in healthy lungs and performs homeostatic function there. However, the exact mechanisms of development of these diseases remain unk…
Introduction. Type 2 diabetes (T2D) is a chronic metabolic disorder. The number of diabetic people is increasing. AKT1 is a protein kinase and a participant in the PI3K/AKT/mTOR signaling pathway. The aim of the study was to analyze the association of polymorp…
Introduction. The study of mechanisms of multicellular system regulation and of cellular proliferation balanced status in the organism tissues is one of the actual task of modern biology and medicine. Purpose of study. Effect of encoded amino acids combination…
Introduction. Hyperglycemia inducers, the «classic» diabetogens streptozotocin and alloxan have a pronounced effect and are therefore limited suitable for modeling mild hyperglycemia in an experiment. Tyloxapol (Triton WR1339) was chosen as an alternative agen…
Studies of post-radiation lesions of the pancreas after irradiation with charged particles (electrons, protons) are few, however, electron therapy is one of the promising methods in radiobiology and can be used to model post-radiation pancreatitis. The mechani…
Introduction. Alkaline phosphatase (ALP) is an enzyme from the class of hydrolases, widely present in human tissues and organs. Intestinal ALP is one of the enzyme isoforms that is expressed in the mucous membrane throughout the intestine and is a marker of in…
Relevance. Ectopic secretion, which occurs in the early stages of tumor development, is not only one of the first signs of a neoplasm, but can also indicate the severity of the oncological process. Purpose of the study: To evaluate the possibility of using the…
Introduction. Studies consider the immune and neuroendocrine systems as actively interacting with each other and priority participating in the complex maintenance of homeostasis. Immune processes are dependent on the functional activity of the endocrine system…
Introduction. Oxidative stress (OS) occurs in various pathological processes, and acting as a nonspecific link in their pathogenesis. Less is known about its physiological role. The aim of study. Analysis of the results of world literature data and our own res…
The use of big data in medical practice is a promising direction in the development of digital personalised medicine. Legal regulation of the use of big data in medical practice is a relevant issue. Legal regulation of the use of big data is based on the need …
Introduction. Thyroid disease is currently the most common among endocrine pathology. Hyperproduction of thyroid hormones is accompanied by stimulation of humoral reactions, contributing to the development of immune-mediated pathology under certain conditions,…
The alkaloids solanine and chaconine were discovered in 1821. However, its did not find medical use due to toxicity. At present, modern research methods have revealed anti-cancer activity of the alcaloids. In this regard, the hypothesis of the presence of othe…
Introduction. Paratraumatic eczema (PTE), being a type of microbial eczema, occurs after surgical interventions, chronic wound healing, accompanied by pronounced inflammatory changes with hyperemia, edema, exudation, soreness and itching. Genetic polymorphisms…
Introduction. Immobilization stress leads to the intensification of free-radical reactions leading to the destruction of sialoglycoproteins of the gastroduodenal zone. The aim of the study. To evaluate the features of the metabolism of sialoglycoproteins in th…
Aim of the study was to establish the significance of TR-receptor, P2X1-receptor and P2Y-receptor synergism for the efficiency of TC aggregation in patients with different sensitivity to non-selective NSAIDs, which will allow us to approach an understanding th…