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Molecular Medicine
Found: 848
Aim of the study was to establish the significance of TR-receptor, P2X1-receptor and P2Y-receptor synergism for the efficiency of TC aggregation in patients with different sensitivity to non-selective NSAIDs, which will allow us to approach an understanding th…
Introduction. Activation of the pro-inflammatory phenotype of microglia may be one of the causes of chronic neuroinflammation and, as a result, can lead to pathological conditions of the brain. The use of neurotrophic factors, such as FGF2, may become one of t…
Introduction. Lung cancer occupies a leading position in the structure of mortality from cancer. Chronic inflammation characteristic of tuberculosis increases the risk of lung cancer. Currently, more and more information is emerging confirming the cause-and-ef…
Introduction. Despite numerous studies in the field of neurodegenerative diseases, the exact mechanisms of these processes have not yet been identified. The purpose of this review is to analyze the methodological approaches necessary to revise the traditional …
Introduction. Sequencing of single cells makes it possible to characterize the cellular and molecular composition of tissues, the state of DNA, RNA and expressed proteins. The «single-cell» sequencing method is gaining increasing popularity in modern biology a…
The computational study of 3D-model hyaluronidase interaction with shortchain glycosaminoglycan ligands had performed demonstrating the diversity and significance of their reaction on enzyme structure. The purpose of this review was evolution of limiting enzym…
Introduction. To date, the problem of studying the neuropeptide system of regulation of adaptive processes is relevant, since the stress reaction is a trigger for the occurrence of various diseases, in particular depression. Corticoliberin is considered as the…
Introduction. Plastic rhinosurgery and augmentation rhinoplasty are very relevant today. Especially in relation to patients with congenital saddle deformity of the nasal dorsum, as well as patients with iatrogenic disorders of the nose shape, which dramaticall…
Introduction. Mitochondrial dysfunction is an important pathogenic mechanism of neurodegeneration, characterized by a progressive structural and functional loss of neurons, leading to heterogeneous clinical and pathological manifestations with subsequent impai…
Introduction. Treatment of the coexistent pathology of lung cancer and tuberculosis remains the prerogative of experimental research, since the optimal treatment strategy for the coexistence of these two diseases has not yet been developed. The purpose was to …
Introduction. Late diagnosis of inflammatory pathologies leads to increased risks of chronicization of the process, generalization, development of complications, and reduced effectiveness of therapy. Routine methods of clinical laboratory diagnostics often hav…
Introduction. Sepsis is multiple organ dysfunction in response to the generalization of an infectious process. The likelihood of developing sepsis correlates with the value of biochemical parameters, which can serve as prognostic markers. The endothelium, as t…
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality. An important task in cardiology is the search and study of new biomarkers. Scientific interest is actively focused on the study of interleukin-11 (IL-11). The purpose of the literature…
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. The specificity of the immune microenvironment of an organ limits the possibilities of traditional therapeutic and surgical approaches to treatment, therefore one of the mo…
The purpose of the present study was to identify mast cells in brain sections of mice with neuroinflammation induced by intraperitoneal injections of LPS. Material and methods. The subjects of the study were nonlinear mice that received intraperitoneal injecti…
The results of experimental replacement of the bladder wall up to subtotal using multicomponent tissue-engineered structures are presented. Purpose. Development and experimental use of a tissue-engineered structure for replacing various volumes of the bladder …
Introduction. An increasing number of reports of long-term negative consequences of COVID-19, characterized by chronic inflammation, tissue hypoxia, oxidative stress, metabolic changes at the level of all body systems, determines the search for criteria for as…
Introduction. Pathological scars (PS) occur after traumatic injuries, surgical interventions, burns, etc. lead to functional disorders, cosmetic defects, and also significantly affect the quality of life. The results of studies to determine the genetic determi…
Introduction. It is known that in the pathogenesis of caries and non-carious lesions of teeth, an important role is played by enamel resistance, which is determined by numerous factors, among which the structure and physical and mechanical properties of tooth …
Introduction. DNMT3A is one of the most frequently mutated genes in acute myeloid leukemia (AML), and the R882H (G>A) substitution is one of the most common mutations in this gene. Restriction analysis and high resolution melting (HRM) analysis are the most co…