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Molecular Medicine
Found: 196
Introduction authors made an attempt to demonstrate the role of DNA-methylation in pathogenesis of uterine fibroids. The epigenetic aspects based on personal investigations and literary data have been reviewed. The research underlined a perspective of investig…
In acute focal ischemia of the heart and brain similar processes are developing despite the obvious differences in the structure, function, and blood supply of these organs. It was shown that under ischemic conditions synthesis stress induced proteins includin…
The frequency of reported cases of melanoma and related mortality rates continue to increase worldwide. The study of the basic mechanisms of both the initiation and development of this highly aggressive tumour proves to be important for the identification of t…
The review deals with the analysis of experimental results relating to the protective effect of mesenchymal stem cells (MSCs) after the brain damage. We consider two mechanisms of the MSCs action. The first proposed mechanism is associated with the ability of …
Telomerase catalytic subunit hTERT is tightly regulated both at the transcriptional and posttranscriptional levels. One of the regulatory mechanisms is its mRNA alternative splicing. Only full-length form has catalytic activity and the ability to elongate telo…
At present, various antineoplastic agents are widely used to treat cancer. There are certain problems associated with their use, such as the inhibition of the pool of dividing cells, poor tolerance and efficiency. Targeted therapy also has several disadvantage…
In the presented review a new potential risk factor for atherosclerosis and cardiovascular disease such as microflora of the human gastrointestinal tract is considered. The modern concept of lipid metabolism and its effects on human health outlining the basic …
Exosomes are microscopic extracellular vesicles with diametr 30–100 nm, which are secreted by different types of cells and may be detected in normal (blood serum, saliva, urine, breast milk) and pathological (ascite) biological fluids. It was shown that exosom…
This article reviews loop-mediated isothermal amplification (LAMP) technique that since its invention in 2000 has gradually become one of the most popular isothermal amplification technologies. In this paper, we described the mechanism of LAMP reaction, differ…
Preeclampsia is the pregnancy complication characterized by the presence of arterial hypertension and proteinuria. Preeclampsia is the leading cause of maternal and perinatal morbidity and mortality. To date, there are more than 40 advanced theories of etiopat…
The use of haloperidol in clinical practice is often accompanied by the development of severe unwanted adverse side effects from the side of various organs and systems. In the narcological practice the use of antipsychotic drugs is not seldom complicated by ex…
Early endothelialization of the inner surface of cardiovascular grafts is imperative for achieving successful functioning in the body. Biofunctionalization of synthetic materials allows to create biomimetic surfaces by incorporating bioactive molecules capable…
In this brief review there are considered possible reasons for the spread of disease of the multifactorial nature in modern populations from standpoints of the discordance between evolutionary formed genetic diversity and rapidly changing environmental factors…
Alzheimer's disease being the socially significant neurodegenerative disease of the elderly, ranks 6th on the causes of death among somatic pathologies. The molecular mechanisms of Alzheimer's disease still remain unexplored until the end, and the efficacy of …
Staphylococcus aureus – the pathogenic microorganism that can cause as well hospital as community-acquired diseases. The emergence and subsequent spread of strains resistant to many antimicrobial agents, and, above all, methicillin-hospital strains (HA-MRSA) a…
This review covers current concepts on the structure, function, regulation of translation and post-translational modifications of hypoxiainducible factor 1 (HIF-1). In addition, the role of this transcription factor in hypoxia and ischemia is discussed. We foc…
The main purpose of the treatment of bronchial asthma is achievement and maintenance of the control over the symptoms of disease at optimal level. For this purpose in terms of basic therapy there is used inhalation of as glucocorticosteroids as well systemic g…
The review highlights the problem of the influence of the genetic characteristics of patients in the dosage of anticoagulant drugs, the main adverse reaction of taking of which is the internal bleeding. Therapy with anticoagulant drugs is characterized by a wi…
Introduction. Gastric cancer is a global problem for the health systems worldwide. Today it takes the fourth place in the world in the morbidity and the second place in the mortality structure. In Russian Federation, almost 70% of gastric cancer cases are diag…
The literature review provides information on the molecular biology of low-grade malignancy gliomas (LGMG) in children and adolescents. The data on specific genetic aberrations in pilocytic astrocytoma, pleomorphic xantoastrocytoma, subependimal giant cell ast…