Found: 841
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 51–57
Esmedlyaeva D.S., Alekseeva N.P., Dyakova M.E.
Introduction. The search for molecular markers of adverse treatment outcomes in individuals with pulmonary tuberculosis (PT) is relevant due to the worldwide increase in drug resistance of Mycobacterium tuberculosis (MBT) strains to anti-tuberculosis drugs (PT…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 43–50
Mitrofanova L.B., Rasulov Z.M., Vorobieva O.M., Gorshkov A.N., Sterkhova K.A., Ulitin A.Yu
Cortical dyslamination with neuronal dysmorphism that occurs adjacent to an arteriovenous malformation (AVM) and is accompanied by epilepsy (E) is classified as FCD IIIc. Its etiology and pathogenesis have yet to be determined. Objective: to clarify the cellul…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 39–42
Ryzhak G.A., Chalisova N.I., Ivanova P.N., Egozova E.S.
Introduction. The study of mechanisms of multicellular system regulation and of cellular proliferation and apoptosis balanced status in the organism tissues is one of the actual task of modern biology and medicine. Purpose of study. Effect of polypeptide compl…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 29–38
Alieva G.V., Garayeva G.G.
Introduction: Great progress has been made in the treatment of arterial hypertension (AH). However, despite the fact that new technologies have paved the way for practical medicine, the number of deaths and disabilities from diseases of the cardiovascular syst…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 22–28
Namiot E.D., Morozova G.D., Sadykov A.R., Logvinenko A.A., Yurasov V.V., Skalny A.V.
Introduction. Assessment of the status of iron at the individual and population level is an urgent task. However, the interpretation of the results is associated with a number of difficulties. The inflammatory process, disorders of carbohydrate metabolism and …
ОБЗОР2023 · pp. 12–21
Nazarova K.E., Kostromina R.A., Malinovskaya N.A., Khilazheva E.D., Komleva Y.K.
Introduction. Proinflammatory cytokines produced in elevated concentrations in the elderly significantly impair neurogenesis in the dentate gyrus of the hippocampus, long-term potentiality, alter neuronal morphology and function, and increase apoptosis. This l…
ОБЗОР2023 · pp. 3–11
Morozova O.V.
Introduction. Entry of inorganic and organic nanomaterials through respiratory tract, skin and digestive system increases the risks of immunological disorders, hereditary and oncological diseases. Localization and stability of nanoparticles are determined by t…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 60–64
Ishtulin A.F., Korotkova N.V., Matveeva I.V., Ishtulina S.L., Minaev I.V., Ishchenko Е.А.
Introduction. In the publications of many authors, there is evidence that the mechanism of development of chronic prostatitis and varicocele is oxidative stress, leading to a decrease in male fertility. This problem requires a deeper study. The aim of the stud…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 53–59
Shestopalov A.V., Davydov V.V., Tumanyan G.T., Savchuk D.V., Teplyakova E.D., Shin V.F., Grigorieva T.V., Laikov A.V., Borisenko O.V., Roumiantsev S.A.
Introduction. There is take place increasing in the incidence of obesity among children and adolescents in the world. However, until now there are not exist clear views about mechanisms of that phenomenon. The aim of study. The purpose of that work is comparat…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 46–52
Morozova G.D., Sadykov A.R., Logvinenko A.A., Namiot E.D., Yurasov V.V., Skalny A.V.
Introduction. Iron is an essential component of key metabolic processes in the body. Transferrin and ferritin are the main compounds that affect serum iron levels. For a competent diagnosis of iron metabolism disorders, knowledge of the principles of various a…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 39–45
Popova L.Yu., Alemanova G.D., Chainikova I.N., Kudlay D.A., Zlodeeva E.A. Albakasova A.A.
Introduction. Primary immunodeficiency states (PIDs) are a heterogeneous group of innate immune disorders. A feature of the clinical manifestations of PID is that they are nonspecific for specific clinical forms. With untimely diagnosis and the absence of path…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 33–38
Esimbekova A.R., Lapkina E.Z., Ruksha T.G.
Introduction. Among the heterogeneous population of tumor cells, there are so-called dormant and senescent cells located in the G0 phase of the cell cycle. The transition to the G0 phase is a stress response mediated, for example, by treatment with chemotherap…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 25–32
Kudriashov G.G., Vinogradova T.I., Zmitrichenko Yu.G., Dogonadze M.Z., Zabolotnyh N.V., Dyakova M.E., Esmedlyaeva D.S., Gavrilov P.V., Azarov A.A., Tochilnikov G.V., Nefedov A.O., Krylova Yu.S., Yablonskii P.K.
Introduction. Lung cancer and tuberculosis, make a significant affect to the morbidity and mortality of the population in Russia and in the world. Strategy of medication therapy has not been developed for cases when these diseases are combined. The aim of the …
ОБЗОР2023 · pp. 19–24
Nikolaev А.А.
The review is devoted to the analysis of modern ideas about the molecular mechanisms of the development of ferroptosis; the main conditions for the development of this type of cell death are described, and cell markers and targets for the induction of ferropto…
ОБЗОР2023 · pp. 11–18
Bueverova E.L., Zolnikova O.Yu., Dzhakhaya N.L.
Results. During the analysis of the published pathogenesis of celiac disease (CD) is actively discussed. It is assumed that the change in gluten tolerance is formed under the influence of a number of different factors, including genetic predisposition and envi…
ОБЗОР2023 · pp. 3–10
Okladnikova E.V., Zinchenko I.S., Ruksha T.G.
Introduction. Overcoming resistance to anticancer drugs in the treatment of malignant neoplasms is an urgent problem of recent decades. Unfortunately, there is no single mechanism for the development of resistance. Alterations that occur in a normal cell durin…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 56–64
Chalisova N.I., Ryzhak G.A., Egorova E.S.
Introduction. The formation of effective bioregulators for the maintenance of the basic physiological functions, so as polypeptide complexes (PPCs), is one of the actual task of modern biology and medicine. Purpose of study. Effect of combination of polypeptid…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 56–60
Chetveryakov A.V., Tsepelev V.L.
Introduction. A high level of checkpoint co-inhibitors in the tumor microenvironment plays an important role in inhibiting the local immune response, which contributes to the growth and progression of cancer. The aim of the study. We aimed to determine immune …
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 50–55
Osmanova S.O., Osmanov O.O., Alimkhanova A.A.
Introduction. An experimental study of the pathogenetic mechanisms of the development of inflammatory-destructive changes in the joints in animal models was carried out in order to develop new diagnostic strategies for further implementation of the results obt…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 43–49
Kudriashov G.G., Nefedov A.O., Tochilnikov G.V., Zmitrichenko Yu.G., Krylova Yu.S., Dogonadze M.Z., Gavrilov P.V., Azarov A.A., Davydenkova E.A., Vinogradova T.I., Yablonskii P.K.
Introduction. One of the problems of modern medicine is the low efficiency of treatment of patients with a coexistence of lung cancer and active tuberculosis. Optimal treatment regimens for coexistence pathology have not been developed at present. In recent ye…