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POLYMORPHISM ANALYSIS OF THE ACTA2 GENE BY PYROSEQUENCING IN PATIENTS WITH NON-FAMILIAL THORACIC AORTIC ANEURYSMS

Zhukov V.A., Zhernakov A.I., Gavrilyuk N.D., Pinaev A.G., Andronov E.E., Uspenskiy V.E., Irtyuga O.B., Moiseeva O.M.

Introduction. The ACTA2 gene encodes α-actin in aortic smooth muscle cells, and its mutations may cause thoracic aortic aneurysms. Analysis of ACTA2 polymorphism can be used in a complex risk assessment of non-familial thoracic aortic aneurysms. The aim of the…