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Molecular Medicine
Found: 10
Introduction. Glutamate receptors are involved in modulating key T-lymphocyte functions, including proliferation, chemotaxis, and others. In the context of the immunopathogenesis of multiple sclerosis (MS), studying the mechanisms underlying these effects is o…
The purpose of the present study was to test the possibility of identifying hippocampal mossy fiber projections by staining mouse brain sections with antibodies to the claudin-2 protein. Material and methods: the subjects of the study were 9 male wild mice. Se…
Introduction. Activation of the pro-inflammatory phenotype of microglia may be one of the causes of chronic neuroinflammation and, as a result, can lead to pathological conditions of the brain. The use of neurotrophic factors, such as FGF2, may become one of t…
Introduction. Proinflammatory cytokines produced in elevated concentrations in the elderly significantly impair neurogenesis in the dentate gyrus of the hippocampus, long-term potentiality, alter neuronal morphology and function, and increase apoptosis. This l…
Introduction. Activation of glial cells by lipopolysaccharide leads to the release of proinflammatory cytokines and the development of neuroinflammation, which, in turn, affects the processes of neuro- and synaptogenesis. However, the specific mechanisms of ne…
Introduction. Aging is associated with a decrease in the neuro- and synaptogenesis as well as hyperactivation of glial cells, which leads to changes in the morphofunctional state of the nervous tissue of the hippocampus and, as a consequence, a deterioration i…
The neurotrophic hypothesis of depressive disorders has gained widespread recognition nowadays. This review is devoted to the brain-derived neurotrophic factor (BDNF) system in the pathogenesis of depression and major depressive disorder. We describe the struc…
Introduction. Type 2 diabetes mellitus (DM) is a metabolic disease characterized by prolonged hyperglycemia, which can cause various complications. Some studies have reported on the relationship between changes in cerebral metabolism and glucose levels. The ai…
Introduction. We analyzed the hypothesis of cryopreservation of small volumes of nervous tissue (brain slices) without the use of traditional cryoprotectants. The aim of the study. The effects of freezing (-10°C) and rewarming to +37°C examined for changes in …
Introduction. Short-term and long-term memory impairments are the main symptoms of several socially important neurodegenerative disorders, such as Alzheimer disease. For this purpose the pharmacological enhancement of short-term memory is of great interest. No…