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Molecular Medicine Peer-reviewed scientific journal

Found: 6

ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2022 · pp. 50–55

INDUCTION OF APOPTOSIS OF PROSTATE CANCER CELLS BY THE EXTRACT OF THE FRESHWATER SPONGE

Introduction. Prostate cancer (PC) is by far the most commonly diagnosed malignant neoplasm of the urinary system. The pathogenesis and molecular mechanisms of prostate cancer remain incompletely understood. There are reports of the presence in the extracts of…

10.29296/24999490-2022-04-08Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2020

DEVELOPMENT AND VALIDATION OF HPLC-MS/MS METHOD OF DETERMINATION OF A NEW VALPROIC ACID DERIVATIVE AND 1,3,4-THIADIAZOLE IN RAT BRAIN

Introduction. To assess the pharmacokinetic indices of new drugs, it is necessary to develop analytical methods for determining their concentration in biological objects. Purpose of the study. Development and validation of HPLC-mass spectrometric methods for t…

10.29296/24999490-2020-04-06Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2018

THE ROLE OF P53 AND NOXA IN THE PATHOGENESIS OF EARLY MISCARRIAGES

Introduction. Missed and spontaneous abortions are one of the most important causes of the reproductive loss. The aim of the study: to study specialties of mRNA expression of p53 and proteins of its signaling pathway in the decidual tissue at 6–10 weeks of ges…

10.29296/24999490-2018-03-05Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2018

ABERRANT TRANSCRIPTIONAL ACTIVITY OF APOPTOSIS-REGULATING GENES IN MALIGNANT NEOPLASM OF CORPUS UTERI

Introduction. The most common invasive malignant tumor of uterine is endometrial cancer. In process of tissues malignancy the critical role belongs to changes in signaling pathways which regulate apoptosis. The aim of study was to analyze changes in the expres…

10.29296/24999490-2018-01-05Details ↗
Research article2014

GALECTIN-1 INDUCES MITOCHONDRIAL APOPTOTIC PATHWAY IN CD4+ T-CELLS

Introduction. Galectin-1 binds to cell surface glycoprotein and participates in cooperation of immune cells. It is supposed that the CD4+- lymphocytes can be target for immunosuppressive activity of galectin-1. However, there is no sufficient information about…

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