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ОБЗОР2026 · pp. 85–90

ESAT-6 and CFP-10 in tuberculosis immunodiagnostics: molecular and pathogenetic basis, diagnostic potential and limitations

Borodulina E.A., Kudlay D.A., Amosova E.A., Borodulin B.E.

Relevance. Tuberculosis immunodiagnostics is based on the ESAT-6 and CFP-10 antigens (RD1 region of Mycobacterium tuberculosis), which are absent from BCG strains and form the antigenic basis of IGRA and TBST. Their clinical use requires consideration of sever…

10.29296/24999490-2026-05-11Details ↗

ОБЗОР2026 · pp. 104–110

Antigen-specific skin tests for detecting tuberculosis infection before biologic and targeted therapy: molecular and immunological foundations and clinical interpretation

Kudlay D.A., Borodulina E.A., Amosova E.A., Lvova M.A.

Introduction. The expanding use of biologic agents, targeted synthetic drugs, and other immunosuppressive treatments has increased the importance of testing for tuberculosis infection in patients at risk of developing tuberculosis disease. Mycobacterium tuberc…

10.29296/24999490-2026-04-14Details ↗