Search

EPIGENETIC EFFECTS OF MINOR GROOVE BINDING LIGANDS

Shalginskikh N.A., Kirsanov K.I., Lesovaya E.A., Belitskiy G.A., Katz R.A., Yakubovskaya M.G.

The influence of the DNA minor groove binding ligands on epigenetic silencing in eukaryotic human cells has been demonstrated for the first time. Using HeLa cell population that harbors silent GFP-reporter gene under control of the CMV promoter we demonstrated…