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Molecular and biological characteristics of tumor cells in testicular embryonal carcinoma explants

Demyashkin G.A., Belokopytov D.V., Shchekin V.I., Borovaya T.G., Rostovskaya V.V., Tsomartova D.A., Pyatigorskaya N.V., Filippova O.V., Maksarova D.D., Mirontsev A.V.

Introduction. Personalized treatment strategies for embryonal carcinoma, a germ cell tumor, are crucial due to the inherent heterogeneity of the tumor. Existing in vitro models inadequately reflect the native tumor microenvironment. Ex vivo organ culture (EVOC…